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伏立康唑成功治疗由微小毛霉引起的肺部毛霉病。

Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole.

机构信息

Sch Med, Southeast Univ, Nanjing, 210009, People's Republic of China.

Dept Dermatology, Sch Med, Jinling Hosp, Nanjing Univ, Nanjing, 210002, People's Republic of China.

出版信息

Eur J Med Res. 2021 Nov 14;26(1):131. doi: 10.1186/s40001-021-00602-x.

DOI:10.1186/s40001-021-00602-x
PMID:34775981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8591890/
Abstract

BACKGROUND

Mucormycosis is a rare fungal infection occurring chiefly in the lung or the rhino-orbital-cerebral compartment, particularly in patients with immunodeficiency or diabetes mellitus. Among Mucorales fungi, Rhizopus spp. are the most common cause of mucormycosis.

CASE PRESENTATION

We report a case of pulmonary mucormycosis caused by Rhizopus microsporus in a young patient with diabetes but no other apparent risk factors. The diagnosis mainly relied on clinical manifestation, positive pulmonary tissue biopsy, and fungal culture. The patient was successfully treated with posaconazole oral suspension and remains asymptomatic at one-year follow-up.

CONCLUSIONS

Pulmonary mucormycosis is a life-threatening condition and posaconazole is an effective treatment for pulmonary mucormycosis caused by Rhizopus microspores.

摘要

背景

毛霉病是一种罕见的真菌感染，主要发生在肺部或鼻眶脑部位，特别是在免疫功能低下或糖尿病患者中。在毛霉目中的真菌中，根霉属是毛霉病最常见的原因。

病例介绍

我们报告了一例由微小根毛霉引起的肺部毛霉病，发生在一位年轻的糖尿病患者身上，但没有其他明显的危险因素。该诊断主要依赖于临床表现、肺部组织活检阳性和真菌培养。该患者经泊沙康唑口服液治疗后成功治愈，在一年的随访中仍无症状。

结论

肺部毛霉病是一种危及生命的疾病，泊沙康唑是治疗微小根毛霉引起的肺部毛霉病的有效药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e21a/8591890/b4992d5f57f0/40001_2021_602_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e21a/8591890/27f6bead5da8/40001_2021_602_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e21a/8591890/b4992d5f57f0/40001_2021_602_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e21a/8591890/27f6bead5da8/40001_2021_602_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e21a/8591890/b4992d5f57f0/40001_2021_602_Fig2_HTML.jpg

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