天然产物让疟疾吃得更清淡。
A Natural Product Puts Malaria on a Low-Fat Diet.
机构信息
Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK.
Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK.
出版信息
Cell Chem Biol. 2020 Feb 20;27(2):137-139. doi: 10.1016/j.chembiol.2020.02.001.
In this issue of Cell Chemical Biology, Yoo et al. (2020) use chemical proteomics to identify target proteins for the potent antimalarial natural product Salinipostin A. Polypharmacology from targeting multiple parasite serine hydrolases and lipases limits resistance to the compound, making this a promising new approach for treating malaria.
在本期《细胞化学生物学》中，Yoo 等人（2020 年）利用化学蛋白质组学来鉴定强效抗疟天然产物 Salinipostin A 的靶蛋白。通过靶向多种寄生虫丝氨酸水解酶和脂肪酶，多药理学限制了对该化合物的耐药性，这为治疗疟疾提供了一种很有前途的新方法。
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