组合代谢驱动原始到启动的多能性染色质景观。

Combinatorial metabolism drives the naive to primed pluripotent chromatin landscape.

机构信息

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.

Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Department of Comparative Medicine, University of Washington, Seattle, WA, 98109, USA.

出版信息

Exp Cell Res. 2020 Apr 15;389(2):111913. doi: 10.1016/j.yexcr.2020.111913. Epub 2020 Feb 19.

DOI:10.1016/j.yexcr.2020.111913

PMID:32084392

Abstract

Since epigenetic modifications are a key driver for cellular differentiation, the regulation of these modifications is tightly controlled. Interestingly, recent studies have revealed metabolic regulation for epigenetic modifications in pluripotent cells. As metabolic differences are prominent between naive (pre-implantation) and primed (post-implantation) pluripotent cells, the epigenetic changes regulated by metabolites has become an interesting topic of analysis. In this review we discuss how combinatorial metabolic activities drive the developmental progression through early pluripotent stages.

摘要

由于表观遗传修饰是细胞分化的关键驱动因素，因此这些修饰的调控受到严格控制。有趣的是，最近的研究揭示了多能细胞中表观遗传修饰的代谢调控。由于原始（着床前）和初始（着床后）多能细胞之间存在明显的代谢差异，因此受代谢物调控的表观遗传变化成为一个有趣的分析主题。在这篇综述中，我们讨论了组合代谢活性如何通过早期多能阶段推动发育进程。