College of Food & Biology Engineering, Zhejiang Gongshang University, Hangzhou, Zhejiang 310035, China.
College of Food & Biology Engineering, Zhejiang Gongshang University, Hangzhou, Zhejiang 310035, China.
Int J Biol Macromol. 2020 May 15;151:376-383. doi: 10.1016/j.ijbiomac.2020.02.171. Epub 2020 Feb 18.
Natural products belonging to a class of generally-recognized-as-safe biomaterials have exceptional biocompatibility and biodegradability and can be used as delivery vehicles for a variety of functional foods. Adlay (Coix lacryma-jobi), is a nutritious food, rich in various bioactive ingredients. Coix seed oil extract (CSO) is also bioactive but it is sensitive to oxidation. In this study, a bioactive delivery system based on homologous polysaccharides and proteins was developed to deliver coix seed oil. The results show that the CSO nanoparticles have high encapsulation efficiency, narrow particle size distribution, and good stability. Moreover, the fusion of the nanoparticles with the membrane enabled the transport of CSO through the Caco-2 cell monolayer and improved the intestinal permeability. These findings could provide useful information for designing homologous polysaccharide and protein-based delivery systems to increase the bioavailability of lipophilic nutraceuticals in the food industry.
天然产物属于一类被普遍认为安全的生物材料，具有出色的生物相容性和可生物降解性，可用作多种功能性食品的递送载体。薏苡仁（Coix lacryma-jobi）是一种营养丰富的食物，富含各种生物活性成分。薏苡籽油提取物（CSO）也具有生物活性，但对氧化敏感。在本研究中，开发了一种基于同源多糖和蛋白质的生物活性递送系统来递送薏苡籽油。结果表明，CSO 纳米颗粒具有高包封效率、窄粒径分布和良好的稳定性。此外，纳米颗粒与膜的融合使 CSO 能够通过 Caco-2 细胞单层运输，并提高了肠道通透性。这些发现可为设计同源多糖和蛋白质递送系统以提高食品工业中脂溶性营养保健品的生物利用度提供有用信息。
