Giangaspero F, Schiavina M, Sturani C, Mondini S, Cirignotta F
Institute of Anatomic Pathology, University of Bologna, Italy.
Clin Neuropathol. 1988 Sep-Oct;7(5):234-7.
A case of Ondine's curse associated with hypothalamic dysfunction in an 8-year-old boy is described. The neuropathological examination revealed a viral encephalitis affecting the hypothalamus and the brainstem. In the medulla the inflammatory process involved the reticular formation and the nuclei considered to control automatic respiration such as the dorsal motor nucleus of the vagus, the nucleus tractus solitarii and the nucleus ambiguous. Although Ondine's curse following viral infection of the central nervous system has been previously reported this represents the first case of viral encephalitis to be pathologically documentated.
本文描述了一名8岁男孩患与下丘脑功能障碍相关的翁丁氏诅咒综合征的病例。神经病理学检查显示为病毒性脑炎，累及下丘脑和脑干。在延髓，炎症过程涉及网状结构以及被认为控制自主呼吸的核团，如迷走神经背运动核、孤束核和疑核。虽然先前已有中枢神经系统病毒感染后发生翁丁氏诅咒综合征的报道，但这是首例有病理记录的病毒性脑炎病例。
