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评价矛头蝮蛇毒引起的全身炎症反应和肺损伤。

Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom.

机构信息

Laboratory of Venomous Animals and Herpetology, Biology Department, State University of Feira de Santana, Feira de Santana, Brazil.

Postgraduate Program in Biotechnology, State University of Feira de Santana, Feira de Santana, Brazil.

出版信息

PLoS One. 2020 Feb 21;15(2):e0224584. doi: 10.1371/journal.pone.0224584. eCollection 2020.

DOI:10.1371/journal.pone.0224584
PMID:32084665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7035002/
Abstract

This study investigated the systemic inflammatory response and mechanism of pulmonary lesions induced by Crotalus durissus cascavella venom in murine in the state of Bahia. In order to investigate T helper Th1, Th2 and Th17 lymphocyte profiles, we measured interleukin (IL) -2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor (TNF) and interferon gamma (IFN-γ) levels in the peritoneal fluid and macerated lungs of mice and histopathological alterations at the specific time windows of 1h, 3h, 6h, 12h, 24h and 48h after inoculation with Crotalus durissus cascavella venom. The data demonstrated an increase of acute-phase cytokines (IL-6 and TNF) in the first hours after inoculation, with a subsequent increase in IL-10 and IL-4, suggesting immune response modulation for the Th2 profile. The histopathological analysis showed significant morphological alterations, compatible with acute pulmonary lesions, with polymorphonuclear leukocyte (PMN) infiltration, intra-alveolar edema, congestion, hemorrhage and atelectasis. These findings advance our understanding of the dynamics of envenomation and contribute to improve clinical management and antiophidic therapy for individuals exposed to venom.

摘要

这项研究调查了巴伊亚州响尾蛇毒液引起的小鼠肺部病变的全身炎症反应和机制。为了研究辅助性 T 细胞 Th1、Th2 和 Th17 淋巴细胞的特征，我们测量了腹腔液和小鼠肺匀浆中白细胞介素（IL）-2、IL-4、IL-6、IL-10、IL-17、肿瘤坏死因子（TNF）和干扰素γ（IFN-γ）的水平，并在接种响尾蛇毒液后 1h、3h、6h、12h、24h 和 48h 的特定时间窗观察肺部的组织病理学改变。数据显示，接种后最初几小时内急性相细胞因子（IL-6 和 TNF）增加，随后 IL-10 和 IL-4 增加，提示 Th2 表型的免疫应答调节。组织病理学分析显示出与急性肺损伤相一致的显著形态学改变，伴有多形核白细胞（PMN）浸润、肺泡内水肿、充血、出血和肺不张。这些发现加深了我们对中毒动力学的理解，并有助于改善接触毒液的个体的临床管理和抗蛇毒治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/80fed20f6e6c/pone.0224584.g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/89e0666b63ef/pone.0224584.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/8d08990fd700/pone.0224584.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/f5395dade066/pone.0224584.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/80fed20f6e6c/pone.0224584.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/079ed0a1ad48/pone.0224584.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/5f3479a50a9a/pone.0224584.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/a5376ba90fc5/pone.0224584.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/89e0666b63ef/pone.0224584.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/8d08990fd700/pone.0224584.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/f5395dade066/pone.0224584.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198e/7035002/80fed20f6e6c/pone.0224584.g007.jpg

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