Banco de sangre del cordón umbilical, Centro Médico La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México.
Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología, Centro Médico Nacional, Instituto Mexicano del Seguro Social, Ciudad de México, México.
Arch Med Res. 2020 Jan;51(1):54-62. doi: 10.1016/j.arcmed.2019.12.006. Epub 2020 Feb 19.
The umbilical cord blood bank at the Mexican Institute of Social Security (IMSS-CBB) was established in January 2005. This lead to the development of the UCB transplantation program. Herein, we describe the experience generated during these 13 years.
Donor selection, as well as UCB collection, processing, and banking were performed under good manufacturing practices and standard operating procedures. UCB units were thawed, processed, and released for transplantation based on HLA and nucleated cell content.
From January 2005-December 2017, 1,298 UCB units were banked; 164 of them were released for transplantation, and 118 UCB transplants were performed. Ninety-four transplants were performed in pediatric patients and 24 in adults. Sixty percent of them corresponded to patients with leukemia, 19% were patients with marrow failure, and the rest had immunodeficiency, hemoglobinopathy, metabolic disorders, or solid tumors. Engraftment was observed in 67 patients (57% of transplanted patients) and 64% of them were still alive when writing this article. In contrast, only 13 of the 51 (25%) non-engrafting patients were alive. At the time of writing this article, the disease-free survival rate was 37%, and the overall survival rate was 47%, with survival periods of 161-3,721 days.
The IMSS UCB banking and transplantation program has had a significant impact for many IMSS patients. The hematopoietic transplantation program at our institution has benefited from the use of UCB as a source of transplantable cells.
墨西哥社会保障研究所（IMSS-CBB）的脐带血库于 2005 年 1 月成立。这导致了脐血移植计划的发展。在此，我们描述了这 13 年来积累的经验。
根据良好生产规范和标准操作程序进行供者选择以及脐血采集、处理和储存。根据 HLA 和有核细胞含量，解冻、处理和放行 UCB 单位进行移植。
从 2005 年 1 月至 2017 年 12 月，共储存了 1,298 份 UCB 单位；其中 164 份用于移植，共进行了 118 例 UCB 移植。94 例移植给儿科患者，24 例移植给成人患者。其中 60%为白血病患者，19%为骨髓衰竭患者，其余为免疫缺陷、血红蛋白病、代谢紊乱或实体瘤患者。67 例患者（移植患者的 57%）观察到植入，当撰写本文时，其中 64%仍存活。相比之下，51 例未植入患者中仅有 13 例存活。在撰写本文时，无疾病生存率为 37%，总生存率为 47%，生存时间为 161-3721 天。
IMSS 的 UCB 储存和移植计划对许多 IMSS 患者产生了重大影响。本机构的造血移植计划受益于将 UCB 用作移植细胞的来源。
