INSERM U1266, Institute of Psychiatry and Neurosciences, Paris, France.
Department of Biostatistics, INSERM1018, University Hospital Rouen, 76000, Rouen, France.
Eur Arch Psychiatry Clin Neurosci. 2021 Aug;271(5):941-950. doi: 10.1007/s00406-020-01105-2. Epub 2020 Feb 21.
Many pregnant women, in the world, drink caffeine-containing beverages. Maternal caffeine consumption during pregnancy may have adverse effects on foetus but results are conflicting. Our goals were to estimate the prevalence of caffeine use in a cohort of French pregnant women using maternal self-reports and to evaluate the association between caffeine consumption during pregnancy and delivery and newborn characteristics. All pregnant women who gave birth in a large French urban area during a limited period of time were included (in total 724 mothers were included). Coffee, tea or cola consumption as well as pregnancy and neonate characteristics were analysed. The mean consumption of caffeine per day slightly decreased from the first to the third trimester of pregnancy: 587 caffeine users, with a consumption of caffeine of 59.2 ± 61.5 mg/day during the first trimester as compared to 577 consumers (54.3 ± 55.4 mg/day) during the third trimester, respectively. A significant decrease of neonates' birth length was observed when mothers were using at least 100 mg/day (or two cups) of caffeine during the second and third trimesters but this difference was no longer significant after adjustment on potential confounding factors such as tobacco use. The potential existence of other confounders (e.g. poorer dietary habits or other lifestyle variables) that might also be associated with reduced birth length, may not be excluded. Caffeine use during pregnancy was associated with reduced birth length but this effect was no longer significant after adjustment on potential confounding variables.
许多孕妇，在全球范围内，饮用含咖啡因的饮料。母体在怀孕期间摄入咖啡因可能对胎儿有不良影响，但结果存在争议。我们的目标是使用母体自我报告来估计法国孕妇队列中咖啡因使用的流行率，并评估怀孕期间和分娩时咖啡因摄入与新生儿特征之间的关系。在有限的时间内，在法国一个大城市分娩的所有孕妇都包括在内（共有 724 名母亲被纳入）。分析了咖啡、茶或可乐的消费以及妊娠和新生儿的特征。咖啡因的日均摄入量从妊娠早期到中期略有下降：587 名咖啡因使用者，妊娠早期的咖啡因摄入量为 59.2±61.5mg/天，而妊娠晚期的咖啡因摄入量为 577 名消费者（54.3±55.4mg/天）。当母亲在第二和第三孕期每天至少使用 100mg（或两杯）咖啡因时，新生儿的出生长度显著下降，但在调整潜在混杂因素（如吸烟）后，这种差异不再显著。不能排除其他可能的混杂因素（例如较差的饮食习惯或其他生活方式变量）也与出生长度降低有关。怀孕期间摄入咖啡因与出生长度降低有关，但在调整潜在混杂变量后，这种影响不再显著。
