Small Animal Clinical Sciences, University of Saskatchewan, Saskatoon, Sask, Canada.
Equine Research Unit, University of California Davis Veterinary Genetics Laboratory, Davis, CA, USA.
Vet Ophthalmol. 2020 May;23(3):515-525. doi: 10.1111/vop.12749. Epub 2020 Feb 22.
To characterize clinical manifestations, measure frequency, and evaluate risk factors for equine recurrent uveitis (ERU) in Appaloosa horses in western Canada.
145 Appaloosa horses.
Ophthalmic examinations were completed and eyes were classified as having no or mild clinical signs, or moderate, or severe damage from ERU. Clinical signs, age, sex, base coat color, and pattern were recorded. Whole blood and/or mane hair follicles were collected for DNA extraction, and all horses were tested for the leopard complex (LP) spotting pattern allele. Pedigree analysis was completed on affected and unaffected horses, and coefficients of coancestry (CC) and inbreeding (COI) were determined.
Equine recurrent uveitis was confirmed in 20 (14%) horses. The mean age of affected horses was 12.3 years (±5.3; range 3-25). Age was a significant risk factor for ERU diagnosis (OR = 1.15) and classification (OR = 1.19). The fewspot coat pattern was significantly associated with increased risk for ERU compared to horses that were minimally patterned or true solids. The LP/LP genotype was at a significantly greater risk for ERU compared to lp/lp (OR = 19.4) and LP/lp (OR = 6.37). Classification of ERU was greater in the LP/LP genotype compared to LP/lp. Affected horses had an average CC of 0.066, and there was a significant difference in the distribution of CC for affected horses versus the control group (P = .021). One affected horse was the sire or grandsire of nine other affected.
Age, coat pattern, and genetics are major risk factors for the diagnosis and classification of ERU in the Appaloosa.
描述加拿大西部阿帕卢萨马中复发性眼色素层炎（ERU）的临床症状、发病频率和评估其危险因素。
145 匹阿帕卢萨马。
进行眼科检查，根据 ERU 的临床症状将眼睛分为无症状或轻度症状、中度症状或重度症状。记录临床症状、年龄、性别、底色毛色和图案。采集全血和/或马鬃毛囊进行 DNA 提取，所有马均接受 leopard complex（LP）斑点图案等位基因检测。对患病和未患病马进行系谱分析，确定亲缘系数（CC）和近交系数（COI）。
20 匹（14%）马确诊为复发性眼色素层炎。患病马的平均年龄为 12.3 岁（±5.3；范围 3-25 岁）。年龄是 ERU 诊断（OR 1.15）和分类（OR 1.19）的显著危险因素。与最小图案或纯色马相比，少斑点图案与 ERU 的发生风险增加显著相关。与 lp/lp 基因型相比，LP/LP 基因型发生 ERU 的风险显著更高（OR 19.4），与 LP/lp 基因型相比发生 ERU 的风险也显著更高（OR 6.37）。LP/LP 基因型的 ERU 分类高于 LP/lp。患病马的平均 CC 为 0.066，患病马与对照组 CC 的分布差异有统计学意义（P 0.021）。有 1 匹患病马是 9 匹其他患病马的父马或祖父马。
年龄、毛色图案和遗传学是阿帕卢萨马 ERU 诊断和分类的主要危险因素。
