[Effectiveness of spirolactone on the treatment of laryngeal edema and complications after H-uvulopalatopharyngoplasty for patients with obstructive sleep apnea].

To determine whether taking spirolactone orally after H-UPPP may relieve laryngeal edema and complications for patients with obstructive sleep apnea（OSA）. Fifty patients with OSA to undergo H-UPPP operation were randomly divided equally to the intervention group（taking spirolactone 20 mg orally twice a day for 7 days after H-UPPP） or the control group, all patients received conventional therapy after H-UPPP including anti-infection, hemostatic treatment, fluid replacement and expectorant by fogged absorption. The pharyngeal wound, diet, sleep and speaking pronunciation of all patients in each group were evaluated every other day in 7 days postoperation. The minimum oxygen saturation of blood（SaO2） during sleep at night each day and the period needed for staphyledema resolution of all patients were recorded and compared between each group. Postoperatively, the intervention group had significantly slighter bleeding at wound site, better sleep and more legible speaking pronunciation than the control group after 3 days to 5 days（<0.05）. The wound dehiscence of the intervention group was significantly slighter than the control group within 7 days after operation（<0.05）. During 3 days to 7days after operation, the intervention group had a significantly better diet than the control group（<0.05）. The average minimum SaO2during sleep at night in the intervention group was significantly higher than that in the control group from 3 days to 5 days post operation（<0.05）. Period needed for staphyledema resolution in the intervention group（4.1±1.5） days was significantly shorter than that in the control group（5.9±1.8） days （<0.05）. Taking spirolactone orally after H-UPPP may relieve laryngeal edema and complications for OSA patients, and it will also shorten the period needed for staphyledema resolution.