[A型肉毒杆菌毒素在耳鼻咽喉科治疗中的应用现状与前景]
[Application status and prospect of botulinum toxin A in otorhinolaryngological treatment].
作者信息
Xu Y L, Chen J H
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jan;34(1):88-91. doi: 10.13201/j.issn.1001-1781.2020.01.022.
Abstract
Botulinum toxin A is a kind of neurotoxin produced by clostridium botulinum, and has been applied for nearly thirty years in China.The target of BTX-A is to selectively cleave the synaptosome-associated protein of 25 KD molecular mass, commonly abbreviated SNAP-25, thereby inhibiting neurotransmitter release and causing chemodenervation. The potential application of botulinum toxin A in treating the spasmodic dysphonia, hemifacial spasm, tinnitus, rhinitis has been confirmed both in clinical practice and previous studies. This paper is to review comprehensively the application status and the prospect of botulinum toxin A in otorhinolaryngological treatment.
摘要
A型肉毒毒素是由肉毒杆菌产生的一种神经毒素，在中国已应用了近三十年。A型肉毒毒素的作用靶点是选择性切割分子量为25千道尔顿的突触体相关蛋白，通常简称为SNAP - 25，从而抑制神经递质释放并导致化学去神经支配。A型肉毒毒素在治疗痉挛性发声障碍、面肌痉挛、耳鸣、鼻炎方面的潜在应用已在临床实践和以往研究中得到证实。本文旨在全面综述A型肉毒毒素在耳鼻咽喉科治疗中的应用现状及前景。
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Laryngoscope. 2017 May;127(5):1131-1134. doi: 10.1002/lary.26265. Epub 2016 Sep 16.
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Botulinum toxin therapy in Frey's syndrome: a retrospective study of 440 treatments in 100 patients.肉毒杆菌毒素治疗 Frey 综合征：100 例患者 440 次治疗的回顾性研究
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