University Medicine Greifswald, Department of Neurosurgery, Germany.
Dtsch Arztebl Int. 2012 Oct;109(41):667-73. doi: 10.3238/arztebl.2012.0667. Epub 2012 Oct 12.
Hemifacial spasm is a neuromuscular movement disorder characterized by brief or persistent involuntary contractions of the muscles innervated by the facial nerve. Its prevalence has been estimated at 11 cases per 100 000 individuals. Among the patients who were operated on by our team, the mean interval from diagnosis to surgery was 8.2 years, and more than half of them learned of the possibility of surgical treatment only through a personal search for information on the condition. These facts motivated us to write this article to raise the awareness of hemifacial spasm and its neurosurgical treatment among physicians who will encounter it.
This review article is based on a selective literature search and on our own clinical experience.
Hemifacial spasm is usually caused by an artery compressing the facial nerve at the root exit zone of the brainstem. 85-95% of patients obtain moderate or marked relief from local injections of botulinum toxin (BTX), which must be repeated every 3 to 4 months. Alternatively, microvascular decompression has a success rate of about 85%.
Local botulinum-toxin injection is a safe and well-tolerated symptomatic treatment for hemifacial spasm. In the long term, however, lasting relief can only be achieved by microvascular decompression, a microsurgical intervention with a relatively low risk and a high success rate.
面肌痉挛是一种神经肌肉运动障碍,其特征是面神经支配的肌肉短暂或持续的不自主收缩。据估计,其患病率为每 10 万人中有 11 例。在我们团队手术的患者中,从诊断到手术的平均间隔时间为 8.2 年,其中超过一半的人只是通过个人搜索该疾病的信息才了解到手术治疗的可能性。这些事实促使我们撰写这篇文章,以提高医生对面肌痉挛及其神经外科治疗的认识。
这篇综述文章基于选择性文献检索和我们自己的临床经验。
面肌痉挛通常是由动脉在脑干面神经出神经根区压迫面神经引起的。85-95%的患者通过局部注射肉毒毒素(BTX)获得中度或明显缓解,BTX 必须每 3-4 个月重复注射一次。或者,微血管减压术的成功率约为 85%。
局部肉毒毒素注射是一种安全且耐受良好的面肌痉挛对症治疗方法。然而,从长远来看,只有微血管减压术才能实现持久缓解,微血管减压术是一种风险相对较低、成功率较高的微创手术干预措施。