Kasinathan S, Gregalatchoumi S
Department of Biology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Endocrinol Jpn. 1988 Apr;35(2):255-60. doi: 10.1507/endocrj1954.35.255.
It has been reported that melatonin produces either progonadal or antigonadal effects in mammals, depending on the time and mode of administration. Information on the melatonin-effect on the testis in toads indicated varied changes during the breeding and hibernating seasons. The present study in Rana hexadactyla (Lesson), a continuous breeder revealed that administration of melatonin at a dosage of 50 micrograms/frog/day either in the morning or evening for a week inhibited spermatogenesis; however, when melatonin was administered for a longer period, this inhibitory effect was lost. Moreover, treatment with melatonin both in the morning and evening had no net effect on the testes.
据报道，褪黑素在哺乳动物中会产生促性腺或抗性腺作用，这取决于给药时间和方式。关于褪黑素对蟾蜍睾丸影响的信息表明，在繁殖和冬眠季节会有不同的变化。本研究以连续繁殖的六指蛙（莱松）为对象，结果显示，每天以50微克/只青蛙的剂量在早晨或晚上给药一周，会抑制精子发生；然而，当褪黑素给药时间更长时，这种抑制作用就会消失。此外，早晚都用褪黑素处理对睾丸没有净效应。
