Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
J Ethnopharmacol. 2020 May 10;253:112538. doi: 10.1016/j.jep.2019.112538. Epub 2020 Feb 20.
Fenugreek is a traditional herbal medicine that has been used for centuries to treat hyperglycemia, muscle spasms, gastritis, constipation, edema, and other metabolic disorders. Recently, lipid-lowering effects of fenugreek have been identified.
The aim of this systematic review and meta-analysis was to determine and clarify the impact of fenugreek supplementation on anthropometric indices and serum lipid levels.
We searched PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar from inception to June 2019 using relevant keywords. All randomized controlled trials (RCTs) investigating the effects of fenugreek on anthropometric indices and plasma lipids in adults were included. A random-effects model was used for quantitative data synthesis. A sensitivity analysis was conducted using the leave-one-out method.
A meta-analysis of 12 RCTs (14 arms) with 560 participants suggested a significant decrease in plasma concentrations of total cholesterol (WMD = -9.371 mg/dL; 95% CI: -15.419, -3.323, p = 0.002), triglycerides (WMD = -13.776 mg/dL; 95% CI: -26.636, -0.916, p = 0.036), and low density lipoprotein cholesterol (WMD = -6.590 mg/Dl; 95% CI: -13.042, -0.137, p = 0.045), as well as an increase in plasma high density lipoprotein cholesterol (WMD = 3.501 mg/dL; 95% CI: 1.309, 5.692, p = 0.002), while body weight (WMD = 0.223 kg; 95% CI: -0.509, 0.955, p = 0.551) and body mass index (WMD = 0.091 kg/m2; 95% CI: -0.244, 0.426, p = 0.596) were not altered.
Fenugreek supplementation improved lipid parameters in adults. However, to confirm these results, more studies, particularly among hyperlipidemic patients, are needed.
葫芦巴是一种传统草药，几个世纪以来一直被用于治疗高血糖、肌肉痉挛、胃炎、便秘、水肿和其他代谢紊乱。最近，葫芦巴具有降低血脂的作用已被确定。
本系统评价和荟萃分析的目的是确定和阐明葫芦巴补充剂对人体测量指数和血清脂质水平的影响。
我们从成立到 2019 年 6 月使用相关关键字在 PubMed、Scopus、ISI Web of Science、Cochrane 图书馆和 Google Scholar 进行了搜索。所有随机对照试验（RCT）都包括研究葫芦巴对成年人人体测量指数和血浆脂质的影响。使用随机效应模型进行定量数据综合。使用逐一剔除法进行敏感性分析。
对 12 项 RCT（14 个臂）的荟萃分析（共 560 名参与者）表明，血浆总胆固醇浓度显著降低（WMD=-9.371mg/dL；95%CI：-15.419，-3.323，p=0.002）、三酰甘油（WMD=-13.776mg/dL；95%CI：-26.636，-0.916，p=0.036）和低密度脂蛋白胆固醇（WMD=-6.590mg/dL；95%CI：-13.042，-0.137，p=0.045），同时血浆高密度脂蛋白胆固醇升高（WMD=3.501mg/dL；95%CI：1.309，5.692，p=0.002），而体重（WMD=0.223kg；95%CI：-0.509，0.955，p=0.551）和体重指数（WMD=0.091kg/m2；95%CI：-0.244，0.426，p=0.596）没有改变。
葫芦巴补充剂可改善成年人的血脂参数。然而，为了证实这些结果，需要开展更多的研究，特别是在高脂血症患者中。
