Student Research Committee, Tabriz University of Medical Sciences, Tabriz, the Islamic Republic of Iran; Department of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, the Islamic Republic of Iran.
Department of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, the Islamic Republic of Iran.
Pharmacol Res. 2023 Jan;187:106594. doi: 10.1016/j.phrs.2022.106594. Epub 2022 Dec 5.
Metabolic syndrome (MetS) is a cluster of metabolic disorders with a heavy disease burden. Fenugreek was reported to be effective in some components of MetS. Therefore, a comprehensive review and meta-analysis of randomized controlled trials was conducted to study the effects of fenugreek on MetS indices. From the beginning until August 2022, PubMed, Embase, Scopus, and Web of science were searched. Data were analyzed using the random-effect model, and presented as weighted mean difference (WMD) and associated 95 % confidence interval (CI). This meta-analysis comprised from a total of 29 eligible RCTs with 31 arms measuring fasting plasma glucose (FPG), Triglyceride (TG), high-density lipoprotein (HDL), waist circumference (WC), systolic blood pressure (SBP), and diastolic blood pressure (DBP). The results indicated significant improving effects of fenugreek on FPG (WMD: -16.75 mg/dL; 95 % CI: -23.36, -10.15; P < 0.001), TG (-20.12 mg/dL; 95 % CI: -34.238, -5.994; P < 0.001), HDL (WMD: 3.55 mg/dL; 95 % CI: 1.98, 5.12; P < 0.001), WC (WMD: -2.51; 95 % CI: -3.78, -1.24; P < 0.001) and SBP (WMD: -3.45 mmHg; 95 % CI: -6.38, -0.52; P = 0.021); However the effect on DBP (WMD: 3.17; 95 % CI: -5.40, 11.73; P = 0.469) and BMI (WMD: -0.40 kg/m2; 95 % CI: -1.114, 0.324; P = 0.281) was not significant. Administration of fenugreek can meaningfully reduce FPG, TG, WC, and SBP and increase HDL. The overall results support possible protective and therapeutic effects of fenugreek on MetS parameters.
代谢综合征（MetS）是一组代谢紊乱的病症，具有沉重的疾病负担。葫芦巴被报道在 MetS 的某些成分中有效。因此，进行了一项全面的综述和荟萃分析，以研究葫芦巴对 MetS 指标的影响。从开始到 2022 年 8 月，检索了 PubMed、Embase、Scopus 和 Web of science。使用随机效应模型分析数据，并以加权均数差（WMD）和相关 95%置信区间（CI）表示。这项荟萃分析共纳入了 29 项符合条件的 RCT，其中 31 个研究臂测量了空腹血糖（FPG）、甘油三酯（TG）、高密度脂蛋白（HDL）、腰围（WC）、收缩压（SBP）和舒张压（DBP）。结果表明，葫芦巴对 FPG（WMD：-16.75mg/dL；95%CI：-23.36，-10.15；P<0.001）、TG（-20.12mg/dL；95%CI：-34.238，-5.994；P<0.001）、HDL（WMD：3.55mg/dL；95%CI：1.98，5.12；P<0.001）、WC（WMD：-2.51；95%CI：-3.78，-1.24；P<0.001）和 SBP（WMD：-3.45mmHg；95%CI：-6.38，-0.52；P=0.021）有显著的改善作用；然而，对 DBP（WMD：3.17mmHg；95%CI：-5.40，11.73；P=0.469）和 BMI（WMD：-0.40kg/m2；95%CI：-1.114，0.324；P=0.281）的影响不显著。给予葫芦巴可显著降低 FPG、TG、WC 和 SBP，并增加 HDL。总体结果支持葫芦巴对 MetS 参数可能具有保护和治疗作用。
