a Biotechnology Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.
b Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine , University of Perugia , Perugia , Italy.
Crit Rev Food Sci Nutr. 2018;58(15):2549-2556. doi: 10.1080/10408398.2017.1332572. Epub 2017 Aug 24.
Artichoke is a component of the Mediterranean diet. Therefore, the aim of this meta-analysis was to determine if artichoke extract supplementation affected human lipid parameters. The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases up to March 28, 2017, to identify RCTs investigating the impact of artichoke extracts on plasma lipid levels. Quantitative data synthesis was performed using a random-effects model, with weighed mean difference (WMD) and 95% confidence interval (CI) as summary statistics. Meta-analysis of data from 9 trials including 702 subjects suggested a significant decrease in plasma concentrations of total cholesterol (WMD: -17.6 mg/dL, 95%CI: -22.0, -13.3, p < 0.001), Low Density Lipoprotein-Cholesterol (LDL-C; WMD: -14.9 mg/dL, 95%CI: -20.4, -9.5, p = 0.011) and triglycerides (WMD: -9.2 mg/dL, 95%CI: -16.2, -2.1, p = 0.011). No significant alteration in plasma High Density Lipoprotein-Cholesterol (HDL-C) concentrations was observed (WMD: 1.0 mg/dL, 95%CI: -1.1, 3.1, p = 0.333). A significant association between the LDL-lowering effect of artichoke and baseline LDL-C concentrations (slope: -0.170; 95%CI: -0.288, 0.051; p = 0.005) was observed. Thus, supplementation with artichoke extract was associated with a significant reduction in both total and LDL-C, and triglycerides, suggesting that supplementation may be synergistic with lipid-lowering therapy in patients with hyperlipidemia.
朝鲜蓟是地中海饮食的组成部分。因此，本荟萃分析的目的是确定朝鲜蓟提取物补充剂是否影响人体脂质参数。检索包括 PubMed-Medline、Scopus、Web of Science 和 Google Scholar 数据库，截至 2017 年 3 月 28 日，以确定研究朝鲜蓟提取物对血浆脂质水平影响的 RCT。使用随机效应模型进行定量数据综合，以加权均数差（WMD）和 95%置信区间（CI）作为汇总统计量。对 9 项试验（包括 702 名受试者）的数据进行荟萃分析表明，总胆固醇（WMD：-17.6mg/dL，95%CI：-22.0，-13.3，p <0.001）、低密度脂蛋白胆固醇（LDL-C；WMD：-14.9mg/dL，95%CI：-20.4，-9.5，p = 0.011）和甘油三酯（WMD：-9.2mg/dL，95%CI：-16.2，-2.1，p = 0.011）的血浆浓度显著降低。高密度脂蛋白胆固醇（HDL-C）的血浆浓度没有显著变化（WMD：1.0mg/dL，95%CI：-1.1，3.1，p = 0.333）。观察到朝鲜蓟降低 LDL-C 的作用与基线 LDL-C 浓度之间存在显著相关性（斜率：-0.170；95%CI：-0.288，0.051；p = 0.005）。因此，朝鲜蓟提取物补充与总胆固醇和 LDL-C以及甘油三酯的显著降低相关，表明补充可能与高脂血症患者的降脂治疗协同作用。
