系统性硬化症中的 CD21+B 细胞：血管并发症的一个可能标志物。
CD21 B cells in systemic sclerosis: A possible marker of vascular complications.
机构信息
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.
Department of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, Rome, Italy.
出版信息
Clin Immunol. 2020 Apr;213:108364. doi: 10.1016/j.clim.2020.108364. Epub 2020 Feb 19.
OBJECTIVES
To evaluate expansion of CD21 B cells and their role in B cell homeostasis, apoptosis, clinical manifestations and serum vascular endothelial growth factor (VEGF) in systemic sclerosis (SSc).
MATERIALS AND METHODS
B-cells subpopulations and apoptosis have been assessed in 74 SSc patients and 20 healthy donors. Renal Doppler ultrasound, echocardiography, pulmonary function test and VEGF were performed.
RESULTS
SSc patients with expanded CD21 B cells (SSc-CD21) show a distinct B cell profile with increased memory B cells compared to patients without CD21 B cells (SSc-CD21). Renal resistive index, systolic pulmonary arterial pressure and FVC/DLCO ratio were significantly higher in SSc-CD21 group than SSc-CD21, DLCO was lower in SSc-CD21 group than SSc-CD21. We found a positive linear correlation between CD21 and sPAP, RI and FVC/DLCO ratio whereas a negative correlation was observed between CD21 and DLCO and VEGF levels.
CONCLUSIONS
CD21 B cells are increased in SSc patients with visceral vascular manifestations.
目的
评估 CD21 B 细胞的扩增及其在 B 细胞动态平衡、凋亡、临床表现和血清血管内皮生长因子（VEGF）中的作用在系统性硬化症（SSc）中的作用。
材料和方法
在 74 例 SSc 患者和 20 名健康供体中评估了 B 细胞亚群和凋亡。进行了肾多普勒超声、超声心动图、肺功能检查和 VEGF 检测。
结果
与无 CD21 B 细胞的 SSc 患者（SSc-CD21）相比，具有扩增 CD21 B 细胞（SSc-CD21）的 SSc 患者表现出明显的 B 细胞特征，记忆 B 细胞增加。SSc-CD21 组的肾血管阻力指数、收缩期肺动脉压和 FVC/DLCO 比值明显高于 SSc-CD21，而 SSc-CD21 组的 DLCO 低于 SSc-CD21。我们发现 CD21 与 sPAP、RI 和 FVC/DLCO 比值呈正线性相关，而与 DLCO 和 VEGF 水平呈负相关。
结论
CD21 B 细胞在有内脏血管表现的 SSc 患者中增加。
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