Blanchard Jack J, Andrea Alexandra, Orth Ryan D, Savage Christina, Bennett Melanie E
Department of Psychology, University of Maryland, College Park, MD 20742, USA.
Department of Psychology, University of Maryland, College Park, MD 20742, USA.
Psychiatry Res. 2020 Feb 7;286:112857. doi: 10.1016/j.psychres.2020.112857.
A large literature indicates that sleep disturbances are associated with paranoia and other positive symptoms in psychotic disorders. However, few studies have examined the potential association between sleep disturbances and negative symptoms and the results have been inconsistent. The current study examined the hypothesis that sleep problems would be associated with more severe positive and negative symptoms in a transdiagnostic sample of individuals with psychosis (N = 90). Further, we examined whether sleep would be related to negative symptoms above and beyond the contribution of paranoia, other positive symptoms, and depression-anxiety. Results replicated prior research in finding that both sleep disturbance and sleep-related impairment were related to more severe paranoia, other positive symptoms and depression-anxiety. Consistent with our hypothesis, more severe sleep disturbance and sleep-related impairment were related to greater negative symptoms; this was evident across both motivation-pleasure deficits and diminished expression. Sleep variables remained significantly related to motivation-pleasure deficits even after controlling for other non-negative symptoms. These results indicate the broad symptom impact of sleep disturbances and may suggest a novel treatment target to improve negative symptoms.
大量文献表明，睡眠障碍与精神障碍中的妄想及其他阳性症状有关。然而，很少有研究探讨睡眠障碍与阴性症状之间的潜在关联，且结果并不一致。本研究检验了这样一个假设：在一个跨诊断的精神病患者样本（N = 90）中，睡眠问题会与更严重的阳性和阴性症状相关。此外，我们还检验了睡眠是否会在妄想、其他阳性症状以及抑郁焦虑之外，与阴性症状相关。研究结果重复了之前的研究，即睡眠障碍和与睡眠相关的损害都与更严重的妄想、其他阳性症状以及抑郁焦虑有关。与我们的假设一致，更严重的睡眠障碍和与睡眠相关的损害与更严重的阴性症状有关；这在动机 - 愉悦缺陷和表情减少两方面都很明显。即使在控制了其他非阴性症状之后，睡眠变量仍与动机 - 愉悦缺陷显著相关。这些结果表明了睡眠障碍对症状的广泛影响，并可能提示一个改善阴性症状的新治疗靶点。
