Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Adv Med Sci. 2020 Mar;65(1):202-213. doi: 10.1016/j.advms.2020.02.002. Epub 2020 Feb 19.
Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, prostate, thymus, testis, ovary, lungs, kidneys, stomach, and adipose tissue. The apelin/APJ axis is involved in a number of physiological and pathological processes. The apelin expression is increased in various kinds of cancer and the apelin/APJ axis plays a key role in the development of tumors through enhancing angiogenesis, metastasis, cell proliferation and also through the development of cancer stem cells and drug resistance. The apelin also stops the apoptosis of cancer cells. The apelin/APJ axis was considered in this review as an attractive therapeutic target for cancer treatment.
Apelin 是一种内源性肽，广泛表达于脑、胎盘、心脏、肺、肾、胰腺、睾丸、前列腺和脂肪组织等多种器官中。Apelin 受体，即血管紧张素样受体 1（APJ），也表达于脑、脾、胎盘、心脏、肝、肠、前列腺、胸腺、睾丸、卵巢、肺、肾、胃和脂肪组织中。Apelin/APJ 轴参与多种生理和病理过程。在各种癌症中，Apelin 的表达增加，并且 Apelin/APJ 轴通过促进血管生成、转移、细胞增殖，以及通过癌症干细胞的发展和耐药性，在肿瘤的发展中起着关键作用。Apelin 还阻止癌细胞凋亡。Apelin/APJ 轴被认为是癌症治疗的一个有吸引力的治疗靶点。
