从未受过伤的伤疤。

The scar that never felt a wound.

机构信息

Division of Nephrology, Department of Internal Medicine III, Carl Gustav Carus University Hospital, Technical University Dresden, Dresden, Germany.

出版信息

Kidney Int. 2020 Mar;97(3):460-462. doi: 10.1016/j.kint.2019.10.006.

DOI:10.1016/j.kint.2019.10.006

PMID:32087889

Abstract

Chronic kidney disease is inevitably associated with the proliferation of fibroblasts following injury of the tubular system and collagen deposition in the interstitial tissue. To date, renal fibrosis has been hard to detect without histologic tissue examination. In this issue of Kidney International, Baues et al. introduce a novel technology for noninvasive detection of renal fibrosis using a multimodal optical approach with the fluorescent-labelled collagen-binding agent CNA35-Cy7.

摘要

慢性肾脏病不可避免地伴随着肾小管系统损伤后成纤维细胞的增殖和间质组织中胶原的沉积。迄今为止，如果不进行组织学检查，很难检测到肾纤维化。在本期《国际肾脏杂志》上，Baues 等人介绍了一种使用荧光标记的胶原结合剂 CNA35-Cy7 的多模态光学方法进行无创检测肾纤维化的新技术。