Lafont O, Cave C, Menager S, Lambrey B, Miocque M
Laboratoire de Chimie Organique, Centre de Pharmacochimie du Madrillet, Faculté de Médecine, Saint-Etienne de Rouvray, France.
Eur J Drug Metab Pharmacokinet. 1988 Apr-Jun;13(2):77-80. doi: 10.1007/BF03191307.
In order to establish if allophanoyl-gamma lactones (B compounds) can pass through the kidney or if only the corresponding delta-hydroxybarbiturates (A compounds), formed by intramolecular alcoholysis, are able to do so, nine experiments were performed to study the urinary excretion of four different allophanoyl gamma-lactones B after administration to dogs. Excreted compounds were extracted, identified and quantised. From the amounts of unmodified administered lactones that were recovered, it is concluded that B compounds can pass through the kidney before isomerisation into the corresponding barbiturates A.
为了确定脲基丙二酸γ-内酯（B化合物）是否能够通过肾脏，或者是否只有通过分子内醇解形成的相应δ-羟基巴比妥酸盐（A化合物）能够通过肾脏，进行了九项实验来研究四种不同的脲基丙二酸γ-内酯B在给犬给药后的尿排泄情况。对排泄出的化合物进行提取、鉴定和定量。从回收的未修饰给药内酯的量可以得出结论，B化合物在异构化为相应的巴比妥酸盐A之前能够通过肾脏。
