大鼠胃中可释放的非神经元性γ-氨基丁酸池

Releasable, non-neuronal GABA pool in rat stomach.

作者信息

Erdö S L, Wolff J R

机构信息

Pharmacological Research Centre, Chemical Works of G. Richter Ltd., Budapest, Hungary.

出版信息

Eur J Pharmacol. 1988 Oct 26;156(1):165-8. doi: 10.1016/0014-2999(88)90160-4.

DOI:10.1016/0014-2999(88)90160-4

PMID:3208839

Abstract

The uptake and K+-evoked release of [3H] gamma-aminobutyric acid (GABA) was examined in tissue slices from rat gastric antrum. Active [3H]GABA accumulation was observed that could only be partially inhibited by L-diaminobutyric acid (L-DABA), a blocker of neuronal GABA uptake. The L-DABA-insensitive uptake component was saturable, sodium-dependent and of high affinity. Moreover, [3H]GABA could be released from this L-DABA-resistant pool by a high K+ concentration. It is concluded that a releasable, non-neuronal GABA pool, which may have some functional significance, is present in the gastric antrum.

摘要

在大鼠胃窦组织切片中检测了[3H]γ-氨基丁酸（GABA）的摄取及钾离子诱发的释放。观察到活跃的[3H]GABA积累，其仅能被神经元GABA摄取阻滞剂L-二氨基丁酸（L-DABA）部分抑制。对L-DABA不敏感的摄取成分是可饱和的、依赖钠且具有高亲和力。此外，高钾浓度可使[3H]GABA从这个对L-DABA有抗性的池中释放出来。结论是胃窦中存在一个可释放的、非神经元性的GABA池，其可能具有一定功能意义。