Department of Physiology and Pathology, Faculty of Medicine, Mu'tah University, Mu'tah, Jordan.
Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan,
Neuroepidemiology. 2020;54(4):326-333. doi: 10.1159/000505971. Epub 2020 Feb 21.
The adolescent and young adult (AYA) age group lacks targeted epidemiologic studies that assess the prevalence and outcome of tumors. We aim to provide deep analysis of the epidemiology of central nervous system (CNS) tumors in AYA in Jordan.
This is a retrospective study for all CNS tumors in the AYA group patients diagnosed and managed at King Hussein Cancer Center in 2007-2016. A patient list was retrieved from the Center's Cancer Registry, and clinicopathologic data were reviewed individually from the patients' records.
A total of 370 cases of primary CNS tumors were retrieved, with a median age of 28.5 years. Males outnumbered females; 57.6 and 42.4%, respectively. Most tumors occurred in the cerebrum (62.2%, n = 230), the frontal lobe was the most commonly affected (29%). Glioma was the most common histologic category (58.9%, n = 218), with high-grade tumors, including glioblastoma and anaplastic astrocytoma, prevailing. Embryonal tumors comprised the second most common group (16.8%, n = 62). Medulloblastoma was the prototype of embryonal tumors (91.9%; n = 57). Glioma tended to affect the older age group than embryonal tumors (p value = 0.002). On last available follow-up, 29.5% were lost to follow-up, 36% were alive, and 34.6% were deceased. The median overall survival (OS) for all tumors was 47.6 months. Embryonal tumors had a better outcome than glioma (median OS 76.3 vs. 30.3 months, respectively; p value = 0.001).
High-grade glioma affecting the cerebrum was the most common tumor among AYA age group and was associated with a less favorable outcome compared to embryonal tumors. More research is needed to address this special age group.
青少年和年轻成年人（AYA）群体缺乏针对评估肿瘤患病率和结局的目标明确的流行病学研究。我们旨在对约旦 AYA 中枢神经系统（CNS）肿瘤的流行病学进行深入分析。
这是一项针对 2007 年至 2016 年在侯赛因国王癌症中心诊断和治疗的 AYA 组中枢神经系统肿瘤患者的回顾性研究。从中心癌症登记处获取患者名单，并单独查阅患者记录中的临床病理数据。
共检索到 370 例原发性中枢神经系统肿瘤，中位年龄为 28.5 岁。男性多于女性，分别为 57.6%和 42.4%。大多数肿瘤发生在大脑（62.2%，n=230），最常受影响的脑叶是额叶（29%）。神经胶质瘤是最常见的组织学类别（58.9%，n=218），高级别肿瘤，包括胶质母细胞瘤和间变性星形细胞瘤，占主导地位。胚胎性肿瘤构成第二常见的组别（16.8%，n=62）。髓母细胞瘤是胚胎性肿瘤的典型代表（91.9%，n=57）。神经胶质瘤比胚胎性肿瘤更倾向于影响年龄较大的人群（p 值=0.002）。在最后一次可获得的随访中，29.5%的患者失访，36%的患者存活，34.6%的患者死亡。所有肿瘤的中位总生存期（OS）为 47.6 个月。胚胎性肿瘤的预后优于神经胶质瘤（中位 OS 分别为 76.3 个月和 30.3 个月，p 值=0.001）。
影响大脑的高级别神经胶质瘤是 AYA 年龄组中最常见的肿瘤，与胚胎性肿瘤相比，其结局较差。需要进一步研究来解决这个特殊的年龄组。
