Department of Internal Medicine, King Hussein Cancer Center, Amman, Jordan.
Office of Scientific Affairs and Research, King Hussein Cancer Center, Amman, Jordan.
Cancer Epidemiol. 2021 Aug;73:101948. doi: 10.1016/j.canep.2021.101948. Epub 2021 May 8.
Glioblastoma (GBM) is the most common primary brain tumor. Epidemiologic studies on GBM are rarely reported in the special age group of adolescents and young adults (AYA) in comparison to other age groups. We aim to present data on GBM in Jordan, with a focus on the AYA age, including the incidence, gender, location and outcome, as well as long term survival (LTS).
Data on GBM was requested from the Jordan Cancer Registry (JCR), and statistical analysis was performed. All data were retrospective and anonymized.
Eight hundred GBM cases were analyzed from 2000 to 2016 including 505 males (63.1 %). Males outnumbered females across are studied years (p-value <0.001). There were 49 pediatrics (0-14 years, 6.1 %), 125 AYA (15-39 years, 15.6 %), 358 adults (40-59 years, 44.8 %) and 268 elderly (60+ years, 33.5 %) cases. Supratentorial location predominated across all age groups (p-value <0.001). The preponderance of males and supratentorial tumors remained across the AYA age group in comparison to others. The median overall survival (OS) was 23.61 months. AYA age group had a better outcome in comparison to the adults/elderly age group (p-value< 0.001). LTS appear to be more common in the AYA age group (p-value 0.021).
This is the first comparative epidemiologic study of GBM in Jordan, focusing on the AYA age group. The AYA age group appears to be associated with a better outcome compared to older age groups, with more LTS compared to others.
胶质母细胞瘤（GBM）是最常见的原发性脑肿瘤。与其他年龄组相比，青少年和年轻成年人（AYA）这一特殊年龄段的 GBM 流行病学研究很少报道。我们旨在展示约旦 GBM 的数据，重点是 AYA 年龄，包括发病率、性别、位置和结果，以及长期生存（LTS）。
从约旦癌症登记处（JCR）请求 GBM 数据，并进行统计分析。所有数据均为回顾性和匿名的。
从 2000 年到 2016 年，分析了 800 例 GBM 病例，包括 505 例男性（63.1%）。在所研究的年份中，男性人数超过女性（p 值<0.001）。有 49 例儿科患者（0-14 岁，6.1%），125 例 AYA（15-39 岁，15.6%），358 例成人（40-59 岁，44.8%）和 268 例老年人（60+岁，33.5%）病例。在所有年龄组中，幕上部位均占优势（p 值<0.001）。与其他年龄组相比，AYA 年龄组中男性和幕上肿瘤的优势仍然存在。总体中位生存期（OS）为 23.61 个月。与成年/老年年龄组相比，AYA 年龄组的结果更好（p 值<0.001）。与其他年龄组相比，AYA 年龄组的 LTS 似乎更为常见（p 值 0.021）。
这是约旦首次针对 GBM 的比较流行病学研究，重点是 AYA 年龄组。与其他年龄组相比，AYA 年龄组的预后似乎更好，与其他年龄组相比，LTS 更多。
