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将宫颈癌机器人辅助根治性子宫切除术的手术技能应用于子宫移植:展望乐观的未来!

Adapting surgical skills from robotic-assisted radical hysterectomy in cervical cancer to uterine transplantation: a look to an optimistic future!

作者信息

Carbonnel Marie, Dahm-Kähler Pernilla, Revaux Aurelie, Brännström Mats, Ayoubi Jean-Marc

机构信息

Department of Obstetrics and Gynecology, Foch Hospital, Suresnes, France.

Department of Obstetrics and Gynecology, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.

出版信息

J Robot Surg. 2020 Dec;14(6):841-847. doi: 10.1007/s11701-020-01058-7. Epub 2020 Feb 22.

DOI:10.1007/s11701-020-01058-7
PMID:32088836
Abstract

Uterus transplantation (UTx) is the first treatment for absolute uterine factor infertility. The first birth after human UTx in Sweden occurred in 2014 and very favourable results of the Swedish trial performed with laparotomy raised great hope. Several teams are leading their own trial among the world, but UTx is still in its experimental phase. Surgical intervention needs to be optimized. The long surgical duration (> 10 h), vascular dissection and risks of ureteral damages for live donors are major drawbacks. Minimal invasive surgery by means of robotic-assisted laparoscopy for live donors could become an improved option. Our collaborative Swedish-French team has initiated efforts to introduce minimal invasive surgery in one trial in Sweden and one in France. UTx is somewhat similar to a radical colpohysterectomy for arterial dissection. We describe a robotic-assisted radical colpohysterectomy and its transposition to uterus retrieval in a living donor. We report our experience on nine cases that were completed prior to our French UTx robot-assisted trial.

摘要

子宫移植(UTx)是治疗绝对子宫因素不孕症的首选方法。2014年,瑞典首例人类子宫移植术后诞生了婴儿,瑞典开腹手术试验取得的非常良好的结果带来了很大希望。世界上有几个团队正在开展各自的试验,但子宫移植仍处于实验阶段。手术干预需要优化。手术时间长(>10小时)、血管解剖以及活体供体输尿管损伤风险是主要缺点。对活体供体采用机器人辅助腹腔镜进行微创手术可能会成为一个更好的选择。我们瑞典-法国合作团队已着手在瑞典和法国的一项试验中引入微创手术。子宫移植在动脉解剖方面与根治性阴道子宫切除术有些相似。我们描述了一种机器人辅助根治性阴道子宫切除术及其在活体供体子宫获取中的应用。我们报告了在法国子宫移植机器人辅助试验之前完成的9例病例的经验。

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Adapting surgical skills from robotic-assisted radical hysterectomy in cervical cancer to uterine transplantation: a look to an optimistic future!将宫颈癌机器人辅助根治性子宫切除术的手术技能应用于子宫移植:展望乐观的未来!
J Robot Surg. 2020 Dec;14(6):841-847. doi: 10.1007/s11701-020-01058-7. Epub 2020 Feb 22.
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Laparotomy or minimal invasive surgery in uterus transplantation: a comparison.剖腹手术与微创子宫移植术的比较。
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Uterus transplantation:robotic surgeon perspective.子宫移植:机器人外科医生视角。
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Evolution of surgical steps in robotics-assisted donor surgery for uterus transplantation: results of the eight cases in the Swedish trial.机器人辅助供体子宫移植手术步骤的演变:瑞典试验中 8 例的结果。
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Robotic surgery for early stage cervical cancer: Evolution and current trends.早期宫颈癌的机器人手术:进展与当前趋势
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How Surgical Research Gave Birth to a New Clinical Surgical Field: A Viewpoint from the Dallas Uterus Transplant Study.外科研究如何催生新的临床外科领域:来自达拉斯子宫移植研究的观点。
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Surgical and oncologic outcomes after robotic radical hysterectomy as compared to open radical hysterectomy in the treatment of early cervical cancer.与开放性根治性子宫切除术相比,机器人根治性子宫切除术治疗早期宫颈癌后的手术及肿瘤学结局。
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Robot-assisted donor hysterectomy in uterus transplantation - a modality to increase reproducibility.机器人辅助供体子宫切除术在子宫移植中的应用——一种提高可重复性的方法。
Ginekol Pol. 2021;92(7):528-531. doi: 10.5603/GP.a2021.0052. Epub 2021 Jun 9.

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Analysis of Predictive Factors for Successful Vascular Anastomoses in a Sheep Uterine Transplantation Model.绵羊子宫移植模型中血管吻合成功的预测因素分析
J Clin Med. 2022 Sep 6;11(18):5262. doi: 10.3390/jcm11185262.
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Case Report: Post-Partum SARS-CoV-2 Infection After the First French Uterus Transplantation.病例报告:法国首例子宫移植术后的产后新型冠状病毒感染
Front Surg. 2022 Jun 28;9:854225. doi: 10.3389/fsurg.2022.854225. eCollection 2022.
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Costimulation Blockade in Vascularized Composite Allotransplantation.血管化复合组织移植中的共刺激阻断。
Front Immunol. 2020 Sep 17;11:544186. doi: 10.3389/fimmu.2020.544186. eCollection 2020.
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Outcome of Recipient Surgery and 6-Month Follow-Up of the Swedish Live Donor Robotic Uterus Transplantation Trial.瑞典活体供体机器人子宫移植试验受者手术结果及6个月随访
J Clin Med. 2020 Jul 22;9(8):2338. doi: 10.3390/jcm9082338.
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Uterus Transplantation with Live Donors: Screening Candidates in One French Center.活体供体子宫移植:法国一家中心的候选者筛选
J Clin Med. 2020 Jun 25;9(6):2001. doi: 10.3390/jcm9062001.