Psychogeriatrics Unit of Hospital de Magalhães Lemos E.P.E., Porto, Portugal.
UNIFAI/ICBAS (Research and Education Unit on Aging), Department of Behavioral Sciences, Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal.
Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317520907168. doi: 10.1177/1533317520907168.
This study investigated how different nutritional and functional status indicators are associated with mortality in patients with Alzheimer's disease (AD). A prospective cohort study was conducted among 79 community-dwelling older adults with AD. Follow-up was 60 months. Undernutrition status was evaluated by Mini Nutritional Assessment (MNA), body mass index, mid-arm muscle circumference (MAMC), calf circumference, and phase angle. Functional status was assessed by handgrip strength, and usual gait speed. Twenty-two participants died (27.8%). Results show that undernutrition (hazard ratio [HR] 5.69, 95% confidence interval [CI] 2.21-14.61), weight loss (HR 3.82, 95% CI 1.37-10.63), underweight (HR 3.24, 95% CI 1.18-8.82), low MAMC (HR 4.54, 95% CI 1.65-12.48), calf circumference ≤ 31 (HR 4.27, 95% CI 1.63-11.16), low HGS (HR 3.11, 95% CI 1.18-8.17), and low gait speed (HR 4.73, 95% CI 1.68-13.27) were all associated with mortality. In conclusion, a poor nutritional and functional status was associated with a higher risk of mortality, regardless of sex, age, marital status, education, and cognitive function.
本研究旨在探讨不同营养和功能状态指标与阿尔茨海默病（AD）患者死亡的相关性。一项前瞻性队列研究纳入了 79 名居住在社区的 AD 老年患者。随访时间为 60 个月。采用微型营养评估（MNA）、体重指数、上臂中部肌肉周长（MAMC）、小腿周长和相位角评估营养不足状态。通过握力和常规步态速度评估功能状态。共有 22 名参与者死亡（27.8%）。结果显示，营养不足（风险比 [HR] 5.69，95%置信区间 [CI] 2.21-14.61）、体重减轻（HR 3.82，95% CI 1.37-10.63）、体重过轻（HR 3.24，95% CI 1.18-8.82）、低 MAMC（HR 4.54，95% CI 1.65-12.48）、小腿周长≤31（HR 4.27，95% CI 1.63-11.16）、握力低（HR 3.11，95% CI 1.18-8.17）和步态速度低（HR 4.73，95% CI 1.68-13.27）均与死亡率相关。总之，无论性别、年龄、婚姻状况、教育程度和认知功能如何，较差的营养和功能状态与较高的死亡风险相关。
