Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Perfusion Solution, Inc., South Euclid, OH, USA.
Int J Artif Organs. 2020 Oct;43(10):677-683. doi: 10.1177/0391398820907104. Epub 2020 Feb 22.
We are developing a novel type of miniaturized left ventricular assist device that is configured for transapical insertion. The aim of this study was to assess the performance and function of a new pump by using a Virtual Mock Loop system for device characterization and mapping. The results, such as pressure-flow performance curves, from pump testing in a physical mock circulatory loop were used to analyze its function as a left ventricular assist device. The Virtual Mock Loop system was programmed to mimic the normal heart condition, systolic heart failure, diastolic heart failure, and both systolic and diastolic heart failure, and to provide hemodynamic pressure values before and after the activation of several left ventricular assist device pump speeds (12,000, 14,000, and 16,000 r/min). With pump support, systemic flow and mean aortic pressure increased, and mean left atrial pressure and pulmonary artery pressure decreased for all heart conditions. Regarding high pump-speed support, the systemic flow, aortic pressure, left atrial pressure, and pulmonary artery pressure returned to the level of the normal heart condition. Based on the test results from the Virtual Mock Loop system, the new left ventricular assist device for transapical insertion may be able to ease the symptoms of patients with various types of heart failure. The Virtual Mock Loop system could be helpful to assess pump performance before in vitro bench testing.
我们正在开发一种新型的微型左心室辅助装置，该装置配置用于经心尖插入。本研究的目的是通过使用虚拟模拟循环系统来评估新泵的性能和功能，以对其进行设备特性描述和映射。从物理模拟循环回路中的泵测试中获得的结果（例如压力-流量性能曲线）用于分析其作为左心室辅助装置的功能。该虚拟模拟循环系统被编程为模拟正常心脏状况、收缩性心力衰竭、舒张性心力衰竭以及收缩性和舒张性心力衰竭，并提供在激活几种左心室辅助装置泵速（12,000、14,000 和 16,000 r/min）之前和之后的血液动力学压力值。在泵的支持下，所有心脏状况下的全身流量和平均主动脉压均增加，而平均左心房压和肺动脉压降低。对于高泵速支持，全身流量、主动脉压、左心房压和肺动脉压恢复到正常心脏状况的水平。根据虚拟模拟循环系统的测试结果，新型经心尖插入的左心室辅助装置可能能够缓解各种类型心力衰竭患者的症状。虚拟模拟循环系统有助于在体外台架测试之前评估泵的性能。
