Abd-Allah Nashwa M, Hassan Amal Aly, Omar Gihan, Hamdy Mona, Abdelaziz Sahar Torky A, Abd El Hamid Waleed Mahmoud, Moussa Rabab A
Department of Rheumatology and Rehabilitation, Faculty of Medicine, Minia University, Minia, Egypt.
Department of Ophthalmology, Faculty of Medicine, Minia University, Minia, Egypt.
Immunol Med. 2020 Jun;43(2):92-97. doi: 10.1080/25785826.2020.1729597. Epub 2020 Feb 23.
The aim of this study was to find the correlation between severity of dry eye and rheumatoid arthritis (RA) disease activity. Forty- two RA patients with dry eye were recruited from Rheumatology Outpatient Clinic in Minia University Hospital. Assessment of RA disease activity was performed using disease activity score (DAS-28). Ocular tests include Schirmer test I, tear film break up time (TBUT) and ocular staining score (OSS) was performed by ophthalmologist to find evidence of ocular dryness. Erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti SSA/Ro and anti SSB/La was also tested. Patients with severe dry (OSS ≥ 3) underwent minor salivary gland biopsy (MSGB) as suspected to have secondary Sjögren's syndrome (SS). Of 42 RA patients, 30 had definite dry eye. DAS-28 did not show significant correlation with any of ocular tests for dryness while the duration of RA was significantly positively correlated with Schirmer test and OSS. The biopsy results of RA patients with severe dry eye show no evidence of SS. The severity of dry eye is not correlated with activity of RA but with its duration.
本研究的目的是找出干眼症严重程度与类风湿关节炎（RA）疾病活动度之间的相关性。从米尼亚大学医院风湿病门诊招募了42例患有干眼症的RA患者。使用疾病活动评分（DAS-28）对RA疾病活动度进行评估。眼科医生进行眼部检查，包括泪液分泌试验I、泪膜破裂时间（TBUT）和眼表染色评分（OSS），以寻找眼干的证据。还检测了红细胞沉降率（ESR）、类风湿因子（RF）、抗SSA/Ro和抗SSB/La。怀疑患有继发性干燥综合征（SS）的重度干眼患者（OSS≥3）接受了小唾液腺活检（MSGB）。在42例RA患者中，30例有明确的干眼症。DAS-28与任何眼部干燥检查均无显著相关性，而RA病程与泪液分泌试验和OSS呈显著正相关。重度干眼RA患者的活检结果未显示SS证据。干眼症的严重程度与RA活动度无关，而与其病程有关。
