Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou450001, China.
Zhengzhou University Library, Zhengzhou University, Zhengzhou450001, China.
Epidemiol Infect. 2020 Feb 24;148:e57. doi: 10.1017/S0950268820000540.
This study aimed at comparing the factors associated with the natural progression between typical progressors (TPs) and rapid progressors (RPs) in HIV-infected individuals. A retrospective study was conducted on 2095 eligible HIV-infected individuals from 1995 to 2016 in a high-risk area of Henan Province, China. Propensity score matching was used to balance covariates, and the conditional logistic regression analyses were performed to explore the factors of natural disease progression among HIV infectors. A total of 379 pairs of RPs and TPs were matched. The standardised difference values of all covariates were less than 10%. HIV-infected individuals transmitted through sexual transmission (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.36-0.85) were more likely to progress to AIDS compared with those infected through contaminated blood. Older age at diagnosis of HIV-infected individuals (OR 0.72, 95% CI 0.58-0.89) exhibited a faster progression to AIDS. HIV-infected individuals identified through a unique survey (OR 7.01, 95% CI 2.99-16.44) were less likely to progress to AIDS compared with those identified through medical institutions. HIV-infected individuals who had higher baseline CD4+T cell counts (OR 3.37, 95% CI 2.59-4.38) had a slower progression to AIDS. These findings provide evidence for natural disease progression from HIV to AIDS between TPs and RPs.
本研究旨在比较 HIV 感染者中自然进展为典型进展者（TPs）和快速进展者（RPs）的相关因素。回顾性研究纳入了 1995 年至 2016 年中国河南省高危地区的 2095 名符合条件的 HIV 感染者。采用倾向评分匹配法平衡协变量，采用条件 logistic 回归分析探讨 HIV 感染者自然疾病进展的相关因素。共匹配了 379 对 RPs 和 TPs。所有协变量的标准化差异值均小于 10%。经性传播感染 HIV（比值比（OR）0.56，95%置信区间（CI）0.36-0.85）的感染者比经污染血液感染的感染者更易进展为艾滋病。诊断为 HIV 感染者时年龄较大（OR 0.72，95%CI 0.58-0.89），艾滋病进展更快。通过独特调查发现的 HIV 感染者（OR 7.01，95%CI 2.99-16.44）比通过医疗机构发现的感染者更不易进展为艾滋病。基线 CD4+T 细胞计数较高的 HIV 感染者（OR 3.37，95%CI 2.59-4.38）艾滋病进展较慢。这些发现为 TPs 和 RPs 之间从 HIV 到 AIDS 的自然疾病进展提供了证据。
