Department of Hematology and Oncology, Mays Cancer Center at UT Health San Antonio MD Anderson, 7979 Wurzbach Road, San Antonio, TX 78229, USA.
Department of Hematology and Oncology, Mays Cancer Center at UT Health San Antonio MD Anderson, 7979 Wurzbach Road, San Antonio, TX 78229, USA.
Hematol Oncol Clin North Am. 2020 Apr;34(2):475-489. doi: 10.1016/j.hoc.2019.11.001. Epub 2019 Dec 25.
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes are rare types of chronic myeloid hematologic neoplasms. Patients with overlap syndrome have similar clinical features, mutations, and disease course, to other chronic myeloid malignancies. Limited data also suggests that overlap syndromes patients experience long standing and at times poorly controlled symptoms that may be underrecognized. In this article, we discuss the etiologies of symptoms in patients with overlap syndromes and currently available symptom burden assessment tools. Overall, symptom burden is an important consideration in patients with overlap syndrome, and efforts are ongoing to further investigate symptom burden and quality of life in this population.
骨髓增生异常综合征/骨髓增殖性肿瘤重叠综合征是罕见的慢性髓系血液肿瘤类型。重叠综合征患者具有与其他慢性髓系恶性肿瘤相似的临床特征、突变和疾病进程。有限的数据还表明，重叠综合征患者存在长期且有时控制不佳的症状，这些症状可能未被充分认识。本文讨论了重叠综合征患者症状的病因以及目前可用的症状负担评估工具。总的来说，症状负担是重叠综合征患者的一个重要考虑因素，目前正在努力进一步研究该人群的症状负担和生活质量。
