成人肾移植受者鼻眶部移植后淋巴组织增生性疾病：病例报告及文献复习。
Post-transplant Lymphoproliferative Disorder of Naso-orbital Region in Adult Renal Transplant Recipients: A Case Report and Literature Review.
机构信息
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
出版信息
Transplant Proc. 2020 Nov;52(9):2731-2735. doi: 10.1016/j.transproceed.2020.01.047. Epub 2020 Feb 20.
Post-transplant lymphoproliferative disorder (PTLD) is an uncommon but fatal complication following both solid organ and hematologic stem cell transplantations. Epstein-Barr virus (EBV) has been considered a main etiologic agent causing PTLD, especially in the first year after transplantation. Extranodal manifestations are frequently found in PTLD; however, naso-orbital involvement in adults is rare. We report a case of EBV-associated PTLD of the naso-orbital region in a 72-year-old patient that occurred 10 years after kidney transplant. Six additional adults with naso-orbital PTLD were identified after completing this literature review, including 2 cases with eyelid swelling, 3 cases with proptosis, and 1 case with facial numbness. The majority of cases occurred after 1 year of transplantation and were associated with EBV. This report emphasizes recognizing PTLD as differential diagnosis in transplant recipients who present with naso-orbital symptoms.
移植后淋巴组织增生性疾病（PTLD）是实体器官和造血干细胞移植后罕见但致命的并发症。EB 病毒（EBV）被认为是导致 PTLD 的主要病因，尤其是在移植后第一年。PTLD 常表现为结外表现，然而，成人鼻眶部受累较为罕见。我们报告了一例肾移植 10 年后发生的、与 EBV 相关的鼻眶部 PTLD，患者为 72 岁男性。在完成这项文献复习后，我们又确定了另外 6 例成人鼻眶部 PTLD，包括 2 例眼睑肿胀，3 例眼球突出，1 例面部麻木。大多数病例发生在移植后 1 年，并与 EBV 相关。本报告强调了在出现鼻眶部症状的移植受者中，将 PTLD 作为鉴别诊断的重要性。
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