Emami Elham, de Grandmont Pierre, Menassa Mélanie, Audy Nicholas, Durand Robert
Faculty of Dentistry, McGill University, Montreal, QC, Canada.
Faculty of Dentistry, Université de Montréal, Montreal, QC, Canada.
Case Rep Med. 2020 Feb 1;2020:6141493. doi: 10.1155/2020/6141493. eCollection 2020.
Knowledge of the risk factors for implant osseointegration is essential for clinical decision-making and optimizing treatment success. This clinical report presents a rare case of implant failure in a patient who received intravitreal injections of a vascular endothelial growth factor (VEGF) inhibitor for the treatment of age-related macular degeneration. Following CARE guidelines, the report presents a case rehabilitated with a mandibular 2-implant overdenture using the immediate-loading protocol and standard procedures. The implants failed within six weeks of immediate loading although primary stability (≥50 Ncm) was achieved during surgery and clinical follow-ups did not show any deviance from standard implant care or patient-related complications. Further investigation suggested that the intake of a VEGF inhibitor may be the cause of failure. This clinical report highlights the importance of systemic risk factors in implant success and their consideration during planning for implant-assisted treatment.
了解种植体骨结合的风险因素对于临床决策和优化治疗效果至关重要。本临床报告介绍了一例罕见的种植失败病例，该患者因年龄相关性黄斑变性接受玻璃体内注射血管内皮生长因子（VEGF）抑制剂治疗。遵循CARE指南，该报告介绍了一例使用即刻负重方案和标准程序通过下颌两颗种植体覆盖义齿进行修复的病例。尽管手术期间实现了初始稳定性（≥50 Ncm），且临床随访未显示与标准种植护理有任何偏差或与患者相关的并发症，但种植体在即刻负重六周内失败。进一步调查表明，摄入VEGF抑制剂可能是失败的原因。本临床报告强调了全身风险因素在种植成功中的重要性以及在规划种植辅助治疗时对其进行考虑的必要性。
