3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, Portugal.
Macromol Biosci. 2010 Jan 11;10(1):12-27. doi: 10.1002/mabi.200900107.
The lack of a functional vascular supply has, to a large extent, hampered the whole range of clinical applications of 'successful' laboratory-based bone tissue engineering strategies. To the present, grafts have been dependent on post-implant vascularization, which jeopardizes graft integration and often leads to its failure. For this reason, the development of strategies that could effectively induce the establishment of a microcirculation in the engineered constructs has become a major goal for the tissue engineering research community. This review addresses the role and importance of the development of a vascular network in bone tissue engineering and provides an overview of the most up to date research efforts to develop such a network.
在很大程度上，缺乏功能性的血管供应限制了“成功”的基于实验室的骨组织工程策略的广泛临床应用。到目前为止，移植物一直依赖于植入后的血管化，这危及移植物的整合，并且常常导致其失败。出于这个原因，开发能够有效地在工程化构建体中诱导建立微循环的策略已成为组织工程研究界的主要目标。本文讨论了在骨组织工程中开发血管网络的作用和重要性，并概述了开发这种网络的最新研究进展。
