Department of Molecular and Developmental Medicine, University of Siena, Policlinico Le Scotte, Viale Bracci, 14, 53100 Siena, Italy.
Department of Agricultural, Food and Environmental Sciences, University of Perugia, Borgo XX Giugno, 74, 06121 Perugia, Italy.
Oxid Med Cell Longev. 2020 Feb 5;2020:7038124. doi: 10.1155/2020/7038124. eCollection 2020.
Almost 50% of infertility cases are associated with human male infertility. The sperm membrane is a key structure influencing sperm morphology and function in normal and pathological conditions. The fatty acid profile determines the performance not only of sperm motility but also of acrosomal reaction and sperm-oocyte fusion. This review presents available knowledge on the role of fatty acid composition in human sperm and spermatogenesis and discusses the influence of dietary fatty acids on the sperm fatty acid profile. Recent studies in biological sciences and clinical researches in this field are also reported. The topic object of this review has potential application in medicine by identifying potential causes of infertility.
近 50%的不孕病例与男性不孕有关。精子膜是影响正常和病理条件下精子形态和功能的关键结构。脂肪酸谱不仅决定了精子运动能力,还决定了顶体反应和精卵融合。本文综述了脂肪酸组成在人类精子和精子发生中的作用,并讨论了膳食脂肪酸对精子脂肪酸谱的影响。还报告了该领域生物科学的最新研究和临床研究。该综述的主题具有识别不孕潜在原因的潜力,因此在医学上具有应用前景。