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IgG 依赖性超氧化物歧化酶在不同类型多发性硬化症患者和健康受试者中的变化。

IgG-Dependent Dismutation of Superoxide in Patients with Different Types of Multiple Sclerosis and Healthy Subjects.

机构信息

Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk 634014, Russia.

Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk 644050, Russia.

出版信息

Oxid Med Cell Longev. 2020 Feb 5;2020:8171020. doi: 10.1155/2020/8171020. eCollection 2020.

DOI:10.1155/2020/8171020
PMID:32089782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7025067/
Abstract

This work is the first to demonstrate that class G immunoglobulins (IgGs) in patients with multiple sclerosis and healthy individuals have the ability to catalyze the dismutation reaction of the superoxide anion radical. Thus, superoxide dismutase (SOD) activity is an intrinsic property of antibodies, which is confirmed by a number of stringent criteria. SOD activity of IgGs in patients with multiple sclerosis statistically significantly exceeds such activity in healthy individuals by 2-4 times. Moreover, the maximum activity has been registered in patients with relapsing remitting multiple sclerosis. The kinetic characteristics of the SOD reaction of IgGs are several orders of magnitude lower than those for the SOD enzyme but do not differ between patients with multiple sclerosis and healthy individuals. Consequently, abzymes with SOD activity have a lower catalysis rate than that of the enzymes and form a stronger complex with the substrates. Inhibitory analysis showed that this activity is inhibited by classical metal-dependent SOD inhibitors. The activity of IgGs was inhibited by classical metal-dependent inhibitors EDTA and TETA (triethylenetetramine). Also, high catalase activity of IgGs was detected in these patients. We suggest that these abzymes help protect the body from oxidative stress.

摘要

这项工作首次表明，多发性硬化症患者和健康个体中的类 G 免疫球蛋白 (IgG) 具有催化超氧阴离子自由基歧化反应的能力。因此，超氧化物歧化酶 (SOD) 活性是抗体的固有特性，这一点已通过多项严格标准得到证实。多发性硬化症患者 IgG 的 SOD 活性比健康个体高 2-4 倍。此外，这种活性在复发缓解型多发性硬化症患者中最高。IgG 的 SOD 反应的动力学特征比 SOD 酶低几个数量级，但在多发性硬化症患者和健康个体之间没有差异。因此，具有 SOD 活性的 abzyme 的催化速率低于酶，并且与底物形成更强的复合物。抑制分析表明，这种活性受到经典的金属依赖性 SOD 抑制剂的抑制。IgG 的活性被经典的金属依赖性抑制剂 EDTA 和 TETA（三乙烯四胺）抑制。此外，还在这些患者中检测到高过氧化氢酶活性。我们认为这些 abzyme 有助于保护身体免受氧化应激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fae1/7025067/1af2839dd8da/OMCL2020-8171020.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fae1/7025067/1af2839dd8da/OMCL2020-8171020.008.jpg

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本文引用的文献

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Catalase activity of IgG antibodies from the sera of healthy donors and patients with schizophrenia.来自健康供体和精神分裂症患者血清中IgG抗体的过氧化氢酶活性。
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