Van De Velde Nicole A, Chatzicharalampous Charalampos, Awonuga Awoniyi O
Resident in Obstetrics and Gynecology, University of Tennessee Health Science Center, USA.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, NYU School of Medicine, NYU Langone Reproductive Specialists of New York, USA.
Case Rep Obstet Gynecol. 2020 Feb 8;2020:9210651. doi: 10.1155/2020/9210651. eCollection 2020.
To describe a case of successful oocyte retrieval, fertilization and clinical pregnancy despite very low -hCG level, twelve hours after ovulation trigger.
Case report. . Academic medical center. . A 38-year-old patient inadvertently administered 2,000 IU hCG for final oocyte maturation; serum hCG twelve hours later was 16 IU/L. . Effort to obtain and administer a booster dose of hCG over the next twenty-seven hours failed. . Successful oocyte retrieval.
Fourteen oocytes were retrieved of which twelve were in metaphase II and nine fertilized after intracytoplasmic sperm injection (ICSI). Of these, eight embryos survived to day 5 and were subjected to preimplantation genetic screening (PGS) by comparative genomic hybridization (CGH). Results were available the next day, three of the embryos were euploid and one was transferred on day 6. Pregnancy was confirmed twelve days later and currently the patient has an ongoing singleton intrauterine pregnancy.
Reproductive Endocrinology and Infertility specialists should be aware that final oocyte maturation could occur following injection of a lower dose of hCG with excellent fertilization rate and embryo development.
描述一例尽管在排卵触发后12小时血清人绒毛膜促性腺激素（hCG）水平极低，但仍成功取卵、受精并实现临床妊娠的病例。
病例报告。学术医疗中心。一名38岁患者无意中注射了2000IU hCG用于最终的卵母细胞成熟；12小时后的血清hCG为16IU/L。在接下来的27小时内试图获取并注射一剂hCG加强针未成功。成功取卵。
共获取14枚卵母细胞，其中12枚处于减数分裂中期II，9枚在卵胞浆内单精子注射（ICSI）后受精。其中，8枚胚胎存活至第5天，并通过比较基因组杂交（CGH）进行植入前基因筛查（PGS）。第二天得到结果，3枚胚胎为整倍体，1枚在第6天移植。12天后确认妊娠，目前该患者正在进行单胎宫内妊娠。
生殖内分泌与不孕不育专家应意识到，注射较低剂量的hCG后仍可发生最终的卵母细胞成熟，且受精率和胚胎发育良好。
