Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Biosci Rep. 2020 Feb 28;40(2). doi: 10.1042/BSR20194405.
Background Primary liver cancer (PLC) is a common type of cancer among men worldwide. Little is known regarding the relationship of liver cancer with ocular metastasis (OM). Drinking has been also reported to be related not only to the occurrence of liver cancer but also to the causes of some ocular lesions. Purpose A diagnostic standard for the levels of serum biomarkers associated with OM derived from liver cancer in men is urgently needed. Material and methods We examined the association between OM in liver cancer and its serum biomarkers. A total of 1254 male patients with liver cancer were recruited in this retrospective study between July 2002 and December 2012. We assessed the relationship between drinking preference and OM in male patients with liver cancer, and aimed to identify an independent prognostic factor or establish a quantitative indicator for OM. Results By assessing the potential indicators, carbohydrate antigen-125 (CA-125), calcium, and hemoglobin (Hb) were found to be most valuable in the diagnosis of OM in male patients with liver cancer. Conclusion CA-125, calcium, and Hb are independent risk factors of OM in patients with liver cancer who consume alcohol.
背景原发性肝癌（PLC）是全球男性中常见的癌症类型。关于肝癌与眼转移（OM）的关系知之甚少。饮酒不仅被报道与肝癌的发生有关，也与一些眼部病变的原因有关。目的迫切需要建立与男性肝癌 OM 相关的血清生物标志物水平的诊断标准。材料与方法我们研究了肝癌 OM 与其血清生物标志物之间的关系。本回顾性研究共纳入 2002 年 7 月至 2012 年 12 月间 1254 名男性肝癌患者。我们评估了男性肝癌患者饮酒偏好与 OM 之间的关系，并旨在确定 OM 的独立预后因素或建立定量指标。结果通过评估潜在指标，发现癌抗原 125（CA-125）、钙和血红蛋白（Hb）在诊断男性肝癌 OM 中最有价值。结论对于饮酒的肝癌患者，CA-125、钙和 Hb 是 OM 的独立危险因素。
