Department of Obstetrics and Gynaecology, Federal Medical Centre, Owerri, Nigeria.
Effective care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria.
Int J Gynaecol Obstet. 2020 May;149(2):171-177. doi: 10.1002/ijgo.13128. Epub 2020 Mar 17.
To compare accuracy between Premaquick (combined test for native insulin-like growth factor binding protein-1 (IGFBP-1), total IGFBP-1, and interleukin-6) and fetal fibronectin (Ffn) in predicting preterm delivery.
Prospective study among women at 28-36 gestational weeks with threatened preterm labor attending Federal Medical Center, Owerri, Nigeria, from August 2017 to February 2019. Cervico-vaginal fluids were collected and tested by Premaquick and Ffn tests. The women were followed for 14 days. Sensitivity, specificity, and negative (NPV) and positive (PPV) predictive value for delivery were compared between the tests.
Among 213 women assessed for eligibility, 183 were enrolled and 175 completed the study. The sensitivity, specificity, PPV, NPV, and accuracy of the Premaquick versus Ffn tests were, respectively, 96.3% versus 51.9%, 97.6% versus 98.4%, 89.7% versus 87.5%, 99.2% versus 90.3% and 97.3% versus 90.0% for preterm delivery within 14 days. Ffn had higher specificity (98.5% vs 97.8%; P>0.99), but Premaquick had higher PPV (92.7% vs 90.9%; P>0.99).
Both tests seem to have high utility in predicting preterm delivery, but Premaquick showed higher accuracy in terms of sensitivity and PPV. Premaquick might be a feasible alternative to Ffn for predicting preterm delivery among symptomatic women in a low-income setting.
比较 Premaquick（用于检测天然胰岛素样生长因子结合蛋白-1（IGFBP-1）、总 IGFBP-1 和白细胞介素-6）和胎儿纤连蛋白（Ffn）在预测早产中的准确性。
这是一项前瞻性研究，纳入了 2017 年 8 月至 2019 年 2 月期间在尼日利亚奥韦里联邦医疗中心就诊的有早产风险的 28-36 孕周孕妇。采集宫颈阴道液并分别用 Premaquick 和 Ffn 进行检测。对这些女性随访 14 天。比较两种检测方法在预测早产方面的灵敏度、特异度、阴性预测值（NPV）和阳性预测值（PPV）。
在评估合格性的 213 名女性中，有 183 名符合条件并纳入研究，175 名完成研究。Premaquick 与 Ffn 检测的灵敏度、特异度、PPV、NPV 和准确性分别为 96.3%与 51.9%、97.6%与 98.4%、89.7%与 87.5%、99.2%与 90.3%和 97.3%与 90.0%，在 14 天内的早产预测中。Ffn 的特异度较高（98.5%比 97.8%；P>0.99），但 Premaquick 的 PPV 较高（92.7%比 90.9%；P>0.99）。
两种检测方法在预测早产方面都具有较高的实用性，但 Premaquick 在灵敏度和 PPV 方面显示出更高的准确性。在资源有限的环境中，对于有症状的孕妇，Premaquick 可能是预测早产的一种可行替代方法。
