Bailey D R, Salmon R K, Berg R T, Fredeen H T
Department of Animal Science, University of Alberta, Edmonton, Canada.
Genome. 1988 Aug;30(4):570-5. doi: 10.1139/g88-096.
To elucidate the influence of high body weight selection on body compositional relationships, the accumulation of lipid, protein, and ash was investigated in two lines of mice selected for high 42-day body weight (H lines) and an unselected foundation population (FP). The two H lines differed in population size and were designated as the high-large (HL) and high-small (HS) lines. Logistic body growth curves revealed that HL mice exhibited an accelerated growth rate and reached a higher mature body weight than FP or HS mice. Over the range of body weights examined, HL mice had more lipid, less protein, and less ash than FP or HS mice of the same sex and body weight. However, HL lipid accumulation (relative to body weight increase) was not accelerated in comparison to that of FP mice. This study suggests that the existing model of selection-mediated compositional changes requires expansion to account for the ability of high-growth selection to direct an acceleration of body growth without a correlated enhancement of the relative rate of fat accumulation.
为阐明高体重选择对身体成分关系的影响，研究了两个经42日龄高体重选择的小鼠品系（H系）和一个未选择的基础群体（FP）中脂质、蛋白质和灰分的积累情况。两个H系在群体大小上有所不同，分别被命名为高大（HL）系和高小（HS）系。逻辑斯蒂身体生长曲线显示，HL小鼠生长速度加快，成熟体重高于FP或HS小鼠。在所研究的体重范围内，与相同性别和体重的FP或HS小鼠相比，HL小鼠的脂质更多，蛋白质和灰分更少。然而，与FP小鼠相比，HL小鼠的脂质积累（相对于体重增加）并未加速。本研究表明，现有的选择介导的成分变化模型需要扩展，以解释高生长选择在不相关增强脂肪积累相对速率的情况下直接加速身体生长的能力。
