Bergmann P, Militzer K, Schmidt P, Büttner D
Central Animal Laboratory, University of Essen, Germany.
Lab Anim. 1995 Jan;29(1):102-9. doi: 10.1258/002367795780740447.
The mouse inbred strain HLG has only recently been submitted for international registration. It has been widely used in radiological studies. Since these mice tend to become obese, they may be of interest for studies concerning fat metabolism. Therefore, the present ageing study examines the sex-specific development of body weight, body composition, adipocyte size as well as the organ weight of liver, heart and thigh muscles of the inbred strain HLG (54 males/53 virgin females) between day 40 and 360 of life. The body weight development showed a distinct sexual dimorphism, quickly increasing in the case of males but comparatively protracted in females until maturity. Significantly higher values for body and fat-free dry weight as well as body water were found in males of all ages. Body fat and adipocyte diameter were only higher in the 80 and 120 day-old males. Thus, the increase in female body weight resulted largely through a rise in body fat as additionally evidenced by the sex-specific correlation of characteristics. A 2-fold analysis of variance showed sex differences in the relative weights of liver and muscle, but not of the heart. A sex-specific close correlation was observed between body and liver weights in males until day 180. Correlations between body fat and other characteristics were only rarely found. Differences in coefficients of variation largely depended on the characteristics. A higher variability was also found for some characteristics in the youngest groups (40 days). A sex-specific difference was only seen in the case of body fat content for 60 day-old mice (female > male).
近交系小鼠HLG最近才提交国际注册申请。它已广泛用于放射学研究。由于这些小鼠容易肥胖，它们可能对脂肪代谢相关研究有意义。因此，本衰老研究考察了近交系HLG（54只雄性/53只未交配雌性）在出生后第40天至360天期间体重、身体组成、脂肪细胞大小以及肝脏、心脏和大腿肌肉器官重量的性别特异性发育情况。体重发育呈现出明显的性别二态性，雄性体重迅速增加，而雌性体重增长相对缓慢，直至成熟。各年龄段雄性的身体重量、无脂肪干重和身体水分含量均显著更高。仅80日龄和120日龄雄性的体脂和脂肪细胞直径更高。因此，雌性体重增加主要是由于体脂增加，这一特征的性别特异性相关性也进一步证明了这一点。双因素方差分析显示，肝脏和肌肉的相对重量存在性别差异，但心脏不存在。直到第180天，雄性的体重与肝脏重量之间存在性别特异性的密切相关性。体脂与其他特征之间的相关性很少见。变异系数的差异很大程度上取决于特征。在最年轻的组（40天）中，一些特征也表现出较高的变异性。仅在60日龄小鼠的体脂含量上观察到性别差异（雌性>雄性）。
