Department of Orthopaedic Surgery, Duke University, Durham, NC, USA.
Department of Orthopedics, Eglin Air Force Base, Eglin AFB, FL, USA.
Expert Rev Med Devices. 2020 Mar;17(3):235-244. doi: 10.1080/17434440.2020.1733973. Epub 2020 Mar 3.
: Osteochondral lesions have been challenging to treat due to the limited regenerative capacity of native hyaline cartilage. Although surgical options are available, a newer technique, Particulated Juvenile Cartilage Allograft Transplantation (PJCAT) has shown promise for lesions of the knee and ankle. Short-term studies have been encouraging of its use, but there is still limited evidence of its long-term durability.: This review will summarize the surgical options currently available for osteochondral lesions, outline the indications and contraindications of PJCAT, present the basic science and clinical evidence of the procedure, and describe the surgical approaches of this technique.: PJCAT is a promising method to treat osteochondral lesions. However, continued research is needed to document the efficacy of this technique and potential superiority over other techniques. Benefits include ease of application, potential for arthroscopic or minimally invasive delivery, no need for perpendicular access, no donor site morbidity, and delivery of viable chondrocytes in hyaline cartilage.
: 由于天然透明软骨的再生能力有限，骨软骨病变的治疗一直具有挑战性。尽管有手术选择，但一种新技术——颗粒状幼年软骨同种异体移植（PJCAT）已显示出对膝关节和踝关节病变的治疗前景。短期研究对其应用持乐观态度，但长期耐久性的证据仍然有限。: 本文综述了目前可用于骨软骨病变的手术选择，概述了 PJCAT 的适应证和禁忌证，介绍了该手术的基础科学和临床证据，并描述了该技术的手术方法。: PJCAT 是治疗骨软骨病变的一种有前途的方法。然而，仍需要进一步的研究来记录该技术的疗效及其相对于其他技术的潜在优势。其优点包括易于应用、潜在的关节镜或微创输送、无需垂直进入、无供区发病率以及透明软骨中可存活的软骨细胞输送。
