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联合颗粒状青少年关节软骨同种异体移植与自体骨移植治疗胫骨平台有症状的骨软骨缺损

Combined Particulated Juvenile Articular Cartilage Allograft Transplantation With Autogenous Bone Graft for Symptomatic Osteochondral Defects in the Tibial Plateau.

作者信息

Walker Paul B, Cope Seth, Trikha Rishi, Kremen Thomas J, Jones Kristofer J

机构信息

Department of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, California, U.S.A.

出版信息

Arthrosc Tech. 2025 Jun 14;14(8):103689. doi: 10.1016/j.eats.2025.103689. eCollection 2025 Aug.

Abstract

Osteochondral lesions of the tibial plateau are rare, comprising only 1% to 2% of knee osteochondritis dissecans cases. Due to their rarity and challenging anatomic location, standardized treatment guidelines remain undefined. We describe a surgical technique combining autogenous bone grafting with particulated juvenile articular cartilage allograft (DeNovo NT; Zimmer Biomet). The advantages of this method include single-stage management, the presence of biologically active juvenile chondrocytes promoting robust hyaline-like cartilage, simultaneous restoration of subchondral bone defects, and enhanced surgical access to an anatomically challenging site.

摘要

胫骨平台骨软骨损伤较为罕见,仅占膝关节剥脱性骨软骨炎病例的1%至2%。由于其罕见性以及解剖位置具有挑战性,标准化的治疗指南尚未明确。我们描述了一种将自体骨移植与颗粒状青少年关节软骨异体移植物(DeNovo NT;捷迈邦美公司)相结合的手术技术。该方法的优点包括一期治疗、存在促进强健透明软骨样生长的生物活性青少年软骨细胞、同时修复软骨下骨缺损以及改善对解剖结构复杂部位的手术入路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f299/12420580/941517446fe1/gr1.jpg

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