Manno Francis A M, Pan Leilei, Mao Yuqi, Su Yang, Manno Sinai H C, Cheng Shuk Han, Lau Condon, Cai Yiling
School of Biomedical Engineering, Faculty of Engineering, University of Sydney; Department of Physics, City University of Hong Kong.
Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University.
J Vis Exp. 2020 Feb 7(156). doi: 10.3791/59837.
The overall goal of this study is to assess the autonomic and behavioral effects of passive motion in rodents using the elevator vertical motion and Ferris-wheel rotation devices. These assays can help confirm the integrity and normal functioning of the autonomic nervous system. They are coupled to quantitative measures based on defecation counting, open-field examination, and balance beam crossing. The advantages of these assays are their simplicity, reproducibility, and quantitative behavioral measures. The limitations of these assays are that the autonomic reactions could be epiphenomena of non-vestibular disorders and that a functioning vestibular system is required. Examination of disorders such as motion sickness will be greatly aided by the detailed procedures of these assays.
本研究的总体目标是使用电梯垂直运动和摩天轮旋转装置评估被动运动对啮齿动物自主神经和行为的影响。这些试验有助于确认自主神经系统的完整性和正常功能。它们与基于排便计数、旷场试验和平衡木穿越的定量测量相结合。这些试验的优点是简单、可重复且具有定量行为测量。这些试验的局限性在于自主反应可能是非前庭疾病的附带现象，并且需要一个功能正常的前庭系统。这些试验的详细程序将极大地有助于对晕动病等疾病的研究。
