Chemistry Laboratory, Faculty of Sciences, University of Douala, Douala, Cameroon.
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan.
Nat Prod Res. 2021 Nov;35(22):4839-4842. doi: 10.1080/14786419.2020.1731740. Epub 2020 Feb 24.
We report the chemistry and biological activities of a Cameroonian Hort. Ex Tanaka, a vegetatively propagated species. The compounds isolated from this plant were determined to be the known 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (), tangerine (), nobilletin (), 5,7,8,4'-tetramethoxyflavone (), citracridone I (), 5-hydroxynoracronycine (), citracridone III (), xanthyletin (), suberosin (), -suberenol (), -methoxysuberenol (), 6-formylumbelliferone (), aurantiamide acetate (), limonin (), stigmasterol, -sitosterol and -sitosterol-3---D-glucoside. The structures of the compounds were established on the basis of their NMR spectroscopic data and comparison with published data. Methanol leaf extract and compounds , , , , and were evaluated for their anti-inflammatory, antioxidant, urease and anti-diabetic effects. Compound showed antioxidant activity, anti-inflammatory effect, urease activity and anti-diabetic activity with IC values of 47.3 µM, 33.5 µM, 25.2 µM and 33.9 µM respectively, values that were comparable to the respective positive standards.
我们报告了一种喀麦隆植物 Hort. Ex Tanaka 的化学和生物活性，这是一种通过营养繁殖的物种。从该植物中分离出的化合物被确定为已知的 5-羟基-6,7,8,3',4'-五甲氧基黄酮（）、橘柚（）、诺比列汀（）、5,7,8,4'-四甲氧基黄酮（）、枸橼酸 I（）、5-羟基去甲育亨宾（）、枸橼酸 III（）、黄皮酰胺（）、菖蒲二烯醇（）、β-蜕皮甾酮（）、β-甲氧基蜕皮甾酮（）、6-甲酰伞形酮（）、aurantiamide 乙酸盐（）、柠檬苦素（）、豆甾醇、β-谷甾醇和β-谷甾醇-3---D-葡萄糖苷。根据其 NMR 光谱数据和与已发表数据的比较，确定了化合物的结构。甲醇叶提取物和化合物、、、、和进行了抗炎、抗氧化、脲酶和抗糖尿病作用的评价。化合物表现出抗氧化活性、抗炎作用、脲酶活性和抗糖尿病活性，IC 值分别为 47.3 μM、33.5 μM、25.2 μM 和 33.9 μM，与各自的阳性标准相当。
