Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majma'ah, Riyadh Province, Saudi Arabia.
Premarital Screening Center, King Khaled General Hospital, Al Majma'ah, Riyadh Province, Saudi Arabia.
Hemoglobin. 2020 Jan;44(1):47-50. doi: 10.1080/03630269.2020.1729175. Epub 2020 Feb 24.
Despite the high prevalence of hemoglobinopathies in Saudi Arabia, the prevalence data in some regions are lacking. Updating the epidemiological survey of hemoglobinopathies at regular intervals is necessary to develop effective prevention and control strategies. Therefore, the primary aim of this study was to determine the prevalence of selected hemoglobinopathies in Saudi adults attending premarital screening at the King Khaled General Hospital (KKGH), Al Majma'ah, Saudi Arabia. The current retrospective study was approved by the Central Institutional Review Board (IRB) of the Ministry of Health (with central IRB log #2019-0039E) and was carried out at the above hospital. The data of the premarital couples, who attended the premarital screening center at KKGH from 1 October 2016 to 30 September 2019, was included in this study. A cation exchange high performance liquid chromatography (HPLC) system was used for screening of the selected hemoglobinopathies. In total, 3755 cases including 1953 (52.01%) males and 1802 (47.99%) females, were screened for hemoglobinopathies. Abnormal hemoglobin (Hb) fractions were observed in 38 (1.01%) cases. The prevalence of β-thalassemia (β-thal) trait was 0.69% (26/3755) and that of sickle cell trait 0.32% (12/3755). Our results showed that the prevalence of β-thal trait is higher than that of sickle cell trait in the adult population of Al Majma'ah. Further comprehensive programs should be carried out to determine the prevalence of hemoglobinopathies in various provinces and cities of Saudi Arabia and other countries. This will help to maintain the updated records of the disease incidence for improving the control measures.
尽管血红蛋白病在沙特阿拉伯很常见，但一些地区缺乏流行数据。定期更新血红蛋白病的流行病学调查对于制定有效的预防和控制策略是必要的。因此，本研究的主要目的是确定在沙特阿拉伯 Al Majma'ah 参加婚前检查的成年人群中选定的血红蛋白病的流行率。这项回顾性研究得到了沙特卫生部中央机构审查委员会（IRB）的批准（中央 IRB 编号为 2019-0039E），并在上述医院进行。该研究纳入了 2016 年 10 月 1 日至 2019 年 9 月 30 日期间在 King Khaled 综合医院婚前检查中心就诊的婚前夫妇的数据。本研究采用阳离子交换高效液相色谱（HPLC）系统对选定的血红蛋白病进行筛查。共有 3755 例患者（包括 1953 例男性和 1802 例女性）接受了血红蛋白病筛查。在 38 例（1.01%）患者中观察到异常血红蛋白（Hb）片段。β-地中海贫血（β-thal）表型的患病率为 0.69%（26/3755），镰状细胞表型的患病率为 0.32%（12/3755）。我们的研究结果表明，在 Al Majma'ah 的成年人群中，β-地中海贫血表型的患病率高于镰状细胞表型。应该进一步开展全面的项目来确定沙特阿拉伯各省市和其他国家的血红蛋白病流行率。这将有助于保持疾病发病率的最新记录，从而改善控制措施。
