血红蛋白病：沙特阿拉伯南部患病率趋势的最新更新。
Hemoglobinopathies: An update on the prevalence trends in Southern Saudi Arabia.
机构信息
From the Department of Clinical Laboratory Sciences (Mohammed, Sultan, Mesfer, Ayed), Faculty of Applied Medical Sciences, King Khalid University, Abha and from the Department of Microbiology (Ali), Armed Forces Hospital, Khamis Mushayt, Kingdom of Saudi Arabia.
出版信息
Saudi Med J. 2021 Jul;42(7):784-789. doi: 10.15537/smj.2021.42.7.20210273.
OBJECTIVES
To investigate trends in hemoglobinopathies following the establishment of a mandatory premarital screening program (MPMSP) in the southern region of Saudi Arabia, where they are considered highly predominant.
METHODS
A retrospective analysis was performed on data from 32,130 high-performance liquid chromatography (HPLC) tests between November 2017 and October 2020. The data was obtained from the Hematology section, Laboratory Department, Armed Forces Hospital, Southern Region.
RESULTS
Despite the establishment of the MPMSP, our data showed that sickle cell disease remains a predominant hemoglobinopathy accounting for more than 7% of total tests in Southern Saudi Arabia. Observed HPLC hemoglobin fractions among the tested population showed a reduction in Hb A mean indicating a high rate of hemoglobin abnormalities. In addition, the prevalence of hemoglobin variants, including sickle cell and thalassemia, was higher in the younger population born after the MPMSP than in older subjects.
CONCLUSION
Even with the implementation of the MPMSP, hemoglobin abnormalities remain prevalent in southern Saudi Arabia. A longer time frame is recommended to verify the validity of the program.
目的
调查沙特阿拉伯南部地区强制性婚前筛查计划（MPMSP）实施后血红蛋白病的趋势，在该地区，血红蛋白病被认为是高度普遍的。
方法
对 2017 年 11 月至 2020 年 10 月期间 32130 例高效液相色谱（HPLC）检测数据进行回顾性分析。数据来自沙特阿拉伯南部地区武装部队医院检验科血液科。
结果
尽管实施了 MPMSP，但我们的数据显示，镰状细胞病仍然是一种主要的血红蛋白病，占南部沙特总检测量的 7%以上。在检测人群中观察到的 HPLC 血红蛋白分数显示 HbA 均值降低，表明血红蛋白异常率较高。此外，血红蛋白变异体（包括镰状细胞和地中海贫血）的患病率在 MPMSP 后出生的年轻人群中高于年龄较大的人群。
结论
即使实施了 MPMSP，血红蛋白异常在沙特阿拉伯南部仍然很普遍。建议延长时间框架以验证该计划的有效性。
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