School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, People's Republic of China.
School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People's Republic of China.
J Org Chem. 2020 Mar 20;85(6):4418-4429. doi: 10.1021/acs.joc.0c00149. Epub 2020 Mar 3.
A copper-catalyzed cascade reaction of diazo compounds with 1,-allenynes ( = 6,7) was reported, which provides efficient access to various functionalized 3-azabicyclo[.2.0] frameworks ( = 5,6) in moderate to excellent yields under mild reaction conditions. The reaction proceeds through intermolecular cross-coupling to form bisallene intermediates, followed by subsequent intramolecular [2+2] cycloaddition.
报道了一种铜催化的重氮化合物与 1,1-烯炔（ = 6,7）的级联反应，该反应在温和的反应条件下以中等至优异的产率提供了各种功能化的 3-氮杂双环[2.0.0]骨架（ = 5,6）的有效途径。该反应通过分子间交叉偶联形成双烯炔中间体，然后进行后续的分子内[2+2]环加成。
