IUF - Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.
IUF - Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.
Neurochem Int. 2020 Jun;136:104708. doi: 10.1016/j.neuint.2020.104708. Epub 2020 Feb 21.
The biological pathways and the extent to which air pollution can affect the cognitive decline in the elderly is not fully understood. In recent years, the impact of air pollution on cognitive impairment has become an active area of epidemiological research and several studies provided supporting evidence. This short review focuses on epidemiological studies in older adults investigating the associations between long-term air pollution exposure and cognitive impairment and decline. Most studies were observational studies and reported assessment of cognitive function using different cognitive scores and air pollution exposure in adults older than 50 years. The results from these studies indicate that exposure to ambient air pollution can have adverse effects on cognitive decline and impairment, but the overall results are heterogeneous and not fully conclusive. The number of epidemiological studies are still limited and additional longer-term studies are needed to confirm the findings. Understanding the relationship between air pollution and cognitive impairment is important to develop preventive measures and to address the needs of people living with cognitive impairment.
空气污染对老年人认知能力下降的影响途径及其程度尚未完全阐明。近年来，空气污染对认知障碍的影响已成为流行病学研究的一个活跃领域，有几项研究为此提供了佐证。本综述重点关注了在老年人中开展的研究，这些研究调查了长期暴露于空气污染与认知障碍和认知能力下降之间的关联。大多数研究为观察性研究，并且使用不同的认知评分和 50 岁以上成年人的空气污染暴露情况，对认知功能进行了评估。这些研究的结果表明，暴露于环境空气污染可能对认知下降和认知障碍产生不良影响，但总体结果存在异质性，且并不完全具有结论性。目前，流行病学研究的数量仍然有限，需要开展更多的长期研究来证实这些发现。了解空气污染与认知障碍之间的关系对于制定预防措施以及满足认知障碍患者的需求非常重要。
