Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School (MHH), Hannover, Germany.
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany.
J Glob Antimicrob Resist. 2020 Sep;22:102-105. doi: 10.1016/j.jgar.2020.02.012. Epub 2020 Feb 21.
Vancomycin-resistant enterococci (VRE) are emerging multidrug-resistant bacteria. They can cause serious nosocomial infections, especially in immunocompromised patients.
In this study, we aimed to determine the burden of intestinal VRE colonization and clinically relevant infection in adult hematologic and oncologic patients at a tertiary care clinic in Germany based on prospective infection surveillance and an active screening program.
In a 12 month period, 132 of 555 patients had intestinal VRE-colonization (23.8%) and four patients (0.7% of the entire cohort, and 3.0% of those colonized with VRE) developed a nosocomial infection with VRE.
The prospective surveillance and active screening for VRE was very useful to determine the true ratio of intestinal colonization to infection and thus helps to shape infection control management.
耐万古霉素肠球菌（VRE）是新兴的多重耐药菌。它们可引起严重的医院获得性感染，尤其是在免疫功能低下的患者中。
本研究旨在通过前瞻性感染监测和主动筛查计划，确定德国一家三级护理诊所成年血液和肿瘤患者的肠道 VRE 定植和临床相关感染的负担。
在 12 个月期间，555 名患者中有 132 名（23.8%）存在肠道 VRE 定植，4 名患者（整个队列的 0.7%，以及 VRE 定植者的 3.0%）发生了 VRE 引起的医院获得性感染。
对 VRE 的前瞻性监测和主动筛查对于确定肠道定植与感染的真实比例非常有用，有助于制定感染控制管理措施。
