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小干扰RNA疗法的药物递送

Drug Delivery of siRNA Therapeutics.

作者信息

Lamberti Gaetano, Barba Anna Angela

机构信息

Eng4Life Srl, Spin-off Accademico, Via Fiorentino, 32, 83100 Avellino, Italy.

Dipartimento di Ingegneria Industriale; Università degli Studi di Salerno, via Giovanni Paolo II, 132 84084 Fisciano (SA), Italy.

出版信息

Pharmaceutics. 2020 Feb 20;12(2):178. doi: 10.3390/pharmaceutics12020178.

DOI:10.3390/pharmaceutics12020178
PMID:32093141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7076510/
Abstract

Small interfering RNA (siRNA) is a class of nucleic acid-based drugs (NABDs) able to block gene expression by interaction with mRNA before its translation [...].

摘要

小干扰RNA（siRNA）是一类基于核酸的药物（NABDs），能够在mRNA翻译前通过与mRNA相互作用来阻断基因表达[……]。

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Drug Delivery of siRNA Therapeutics.小干扰RNA疗法的药物递送
Pharmaceutics. 2020 Feb 20;12(2):178. doi: 10.3390/pharmaceutics12020178.
2
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Mol Ther Nucleic Acids. 2021 Dec 11;27:349-362. doi: 10.1016/j.omtn.2021.12.016. eCollection 2022 Mar 8.

本文引用的文献

1
Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy.用于哮喘治疗中 siRNA 递送的新型聚天冬酰胺共聚物的设计
Pharmaceutics. 2020 Jan 22;12(2):89. doi: 10.3390/pharmaceutics12020089.
2
Aptamers as Delivery Agents of siRNA and Chimeric Formulations for the Treatment of Cancer.适配体作为用于癌症治疗的小干扰RNA和嵌合制剂的递送剂
Pharmaceutics. 2019 Dec 16;11(12):684. doi: 10.3390/pharmaceutics11120684.
3
Efficient Delivery of Therapeutic siRNA by FeO Magnetic Nanoparticles into Oral Cancer Cells.通过FeO磁性纳米颗粒将治疗性小干扰RNA高效递送至口腔癌细胞
Pharmaceutics. 2019 Nov 17;11(11):615. doi: 10.3390/pharmaceutics11110615.
4
Polymeric Nanoparticles Based on Tyrosine-Modified, Low Molecular Weight Polyethylenimines for siRNA Delivery.基于酪氨酸修饰的低分子量聚乙烯亚胺的聚合物纳米颗粒用于小干扰RNA递送
Pharmaceutics. 2019 Nov 12;11(11):600. doi: 10.3390/pharmaceutics11110600.
5
Strategies for Delivery of siRNAs to Ovarian Cancer Cells.将小干扰RNA递送至卵巢癌细胞的策略。
Pharmaceutics. 2019 Oct 22;11(10):547. doi: 10.3390/pharmaceutics11100547.
6
Intracellular Delivery of siRNAs Targeting AKT and ERBB2 Genes Enhances Chemosensitization of Breast Cancer Cells in a Culture and Animal Model.靶向AKT和ERBB2基因的小干扰RNA的细胞内递送增强了培养细胞和动物模型中乳腺癌细胞的化学敏感性。
Pharmaceutics. 2019 Sep 3;11(9):458. doi: 10.3390/pharmaceutics11090458.
7
Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications.用于基于核酸的药物的脂质递送系统：从生产到临床应用
Pharmaceutics. 2019 Jul 24;11(8):360. doi: 10.3390/pharmaceutics11080360.
8
Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled In Silico-Experimental Studies. Part I: Covalent siRNA Nanocarriers.通过计算机辅助实验耦合研究，从共价型到自组装型基于聚酰胺-胺（PAMAM）的树枝状大分子作为癌症中siRNA递送纳米载体的演变。第一部分：共价型siRNA纳米载体。
Pharmaceutics. 2019 Jul 18;11(7):351. doi: 10.3390/pharmaceutics11070351.
9
Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled in Silico-Experimental Studies. Part II: Self-Assembled siRNA Nanocarriers.通过计算机模拟与实验相结合的研究，基于共价键合到自组装的聚酰胺-胺型树枝状大分子作为癌症中siRNA递送纳米载体的演变。第二部分：自组装siRNA纳米载体。
Pharmaceutics. 2019 Jul 10;11(7):324. doi: 10.3390/pharmaceutics11070324.
10
Synergistic Anti-Angiogenic Effects Using Peptide-Based Combinatorial Delivery of siRNAs Targeting VEGFA, VEGFR1, and Endoglin Genes.使用基于肽的组合递送靶向VEGFA、VEGFR1和内皮糖蛋白基因的小干扰RNA的协同抗血管生成作用。
Pharmaceutics. 2019 Jun 6;11(6):261. doi: 10.3390/pharmaceutics11060261.